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T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy
المؤلفون المشاركون
Balog, Attila
Dulic, Sonja
Vásárhelyi, Zsófia
Sava, Florentina
Berta, László
Toldi, Gergely
Kovács, László
Szalay, Balázs
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-25
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Data on the impact of biological therapies on the T-cell phenotype in rheumatoid arthritis are limited.
Here, we prospectively measured the percentages of 15 circulating T-cell subtypes using flow cytometry.
We obtained transversal and longitudinal data in 30 anti-TNF responders, 19 secondary anti-TNF nonresponders, and 43 IL-6R antagonist responders, before, 8 weeks and at least 6 months after biological therapy.
Untreated RA patients and healthy controls were also included.
The important findings are the following: (1) the proportion of regulatory T-cells (Tregs) which are decreased in untreated RA patients becomes normal in all long-term-treated groups; (2) in anti-TNF responders as well as in nonresponders, the frequencies of naïve CD4+ and CD8+ cells are lower, whereas those of proinflammatory Th1, Th2, and Th17 cells and HLA-DR+-activated cells are higher than those in untreated RA or healthy controls; (3) in IL-6R responders, Th1 proportion is decreased, while that of Th2 and Th17 is increased as compared to that in anti-TNF-treated patients and controls; (4) pending confirmation, a CD4CD69 ratio < 2.43 at baseline, could be useful to predict a good therapeutic response to anti-TNF therapy.
This study provides comprehensive information regarding the long-term impacts of those biological therapies on the ecotaxis of T-cells in RA.
The ClinicalTrials.gov registration number of our study is NCT03266822.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dulic, Sonja& Vásárhelyi, Zsófia& Sava, Florentina& Berta, László& Szalay, Balázs& Toldi, Gergely…[et al.]. 2017. T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1188620
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dulic, Sonja…[et al.]. T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy. Mediators of Inflammation No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1188620
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dulic, Sonja& Vásárhelyi, Zsófia& Sava, Florentina& Berta, László& Szalay, Balázs& Toldi, Gergely…[et al.]. T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1188620
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188620
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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