T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy
Joint Authors
Balog, Attila
Dulic, Sonja
Vásárhelyi, Zsófia
Sava, Florentina
Berta, László
Toldi, Gergely
Kovács, László
Szalay, Balázs
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-25
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Data on the impact of biological therapies on the T-cell phenotype in rheumatoid arthritis are limited.
Here, we prospectively measured the percentages of 15 circulating T-cell subtypes using flow cytometry.
We obtained transversal and longitudinal data in 30 anti-TNF responders, 19 secondary anti-TNF nonresponders, and 43 IL-6R antagonist responders, before, 8 weeks and at least 6 months after biological therapy.
Untreated RA patients and healthy controls were also included.
The important findings are the following: (1) the proportion of regulatory T-cells (Tregs) which are decreased in untreated RA patients becomes normal in all long-term-treated groups; (2) in anti-TNF responders as well as in nonresponders, the frequencies of naïve CD4+ and CD8+ cells are lower, whereas those of proinflammatory Th1, Th2, and Th17 cells and HLA-DR+-activated cells are higher than those in untreated RA or healthy controls; (3) in IL-6R responders, Th1 proportion is decreased, while that of Th2 and Th17 is increased as compared to that in anti-TNF-treated patients and controls; (4) pending confirmation, a CD4CD69 ratio < 2.43 at baseline, could be useful to predict a good therapeutic response to anti-TNF therapy.
This study provides comprehensive information regarding the long-term impacts of those biological therapies on the ecotaxis of T-cells in RA.
The ClinicalTrials.gov registration number of our study is NCT03266822.
American Psychological Association (APA)
Dulic, Sonja& Vásárhelyi, Zsófia& Sava, Florentina& Berta, László& Szalay, Balázs& Toldi, Gergely…[et al.]. 2017. T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1188620
Modern Language Association (MLA)
Dulic, Sonja…[et al.]. T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy. Mediators of Inflammation No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1188620
American Medical Association (AMA)
Dulic, Sonja& Vásárhelyi, Zsófia& Sava, Florentina& Berta, László& Szalay, Balázs& Toldi, Gergely…[et al.]. T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1188620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188620