Morita-Baylis-Hillman Adducts Display Anti-Inflammatory Effects by Modulating Inflammatory Mediator Expression in RAW264.7 Cells

المؤلفون المشاركون

Leite, Jacqueline Alves
Araújo, Demetrius A. M.
Rodrigues-Mascarenhas, Sandra
Faheina-Martins, Glaucia V.
Dantas, Bruna Braga
Lima-Júnior, Cláudio G.
Vasconcellos, Mário L. A. A.

المصدر

Mediators of Inflammation

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-07-12

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض

الملخص EN

Inflammatory response plays an important role not only in the normal physiology but also in pathologies such as cancers.

The Morita-Baylis-Hillman adducts (MBHA) are a novel group of synthetic molecules that have demonstrated many biological activities against some parasitic cells such as Plasmodium falciparum, Leishmania amazonensis, and Leishmania chagasi, and antimitotic activity against sea urchin embryonic cells was also related.

However, little is known about the mechanisms induced by MBHA in inflammatory process and its relation with anticancer activity.

The present work investigated the cytotoxicity of three MBHA derivatives (A2CN, A3CN, and A4CN), on human colorectal adenocarcinoma, HT-29 cells, and their anti-inflammatory activities were examined in lipopolysaccharide- (LPS-) stimulated RAW264.7 macrophage cells, being these derivatives potentially cytotoxic to HT-29 cells.

Coincubation with A2CN, A3CN, or A4CN and LPS in RAW264.7 cells inhibited NO production, as well as the production of reactive oxygen species (ROS) was also repressed.

The mRNA expressions of IL-1β and IL-6 were significantly downregulated by such MBHA compounds in RAW264.7 cells, but only A2CN was able to inhibit the COX-2 gene expression.

We also showed that MBHA compounds decreased almost to zero the production of IL-1β and IL-6.

These findings display that such MBHA compounds exhibit anticancer and anti-inflammatory activities.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Faheina-Martins, Glaucia V.& Leite, Jacqueline Alves& Dantas, Bruna Braga& Lima-Júnior, Cláudio G.& Vasconcellos, Mário L. A. A.& Rodrigues-Mascarenhas, Sandra…[et al.]. 2017. Morita-Baylis-Hillman Adducts Display Anti-Inflammatory Effects by Modulating Inflammatory Mediator Expression in RAW264.7 Cells. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188622

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Faheina-Martins, Glaucia V.…[et al.]. Morita-Baylis-Hillman Adducts Display Anti-Inflammatory Effects by Modulating Inflammatory Mediator Expression in RAW264.7 Cells. Mediators of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1188622

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Faheina-Martins, Glaucia V.& Leite, Jacqueline Alves& Dantas, Bruna Braga& Lima-Júnior, Cláudio G.& Vasconcellos, Mário L. A. A.& Rodrigues-Mascarenhas, Sandra…[et al.]. Morita-Baylis-Hillman Adducts Display Anti-Inflammatory Effects by Modulating Inflammatory Mediator Expression in RAW264.7 Cells. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1188622

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1188622