The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection
المؤلفون المشاركون
Pfeffer, Klaus
Behnke, Kristina
Sorg, Ursula R.
Gabbert, Helmut E.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-06
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Lymphotoxin β receptor (LTβR) signaling plays an important role in efficient initiation of host responses to a variety of pathogens, encompassing viruses, bacteria, and protozoans via induction of the type I interferon response.
The present study reveals that after Toxoplasma gondii infection, LTβR−/− mice show a substantially reduced survival rate when compared to wild-type mice.
LTβR−/− mice exhibit an increased parasite load and a more pronounced organ pathology.
Also, a delayed increase of serum IL-12p40 and a failure of the protective IFNγ response in LTβR−/− mice were observed.
Serum NO levels in LTβR−/− animals rose later and were markedly decreased compared to wild-type animals.
At the transcriptional level, LTβR−/− animals exhibited a deregulated expression profile of several cytokines known to play a role in activation of innate immunity in T.
gondii infection.
Importantly, expression of the IFNγ-regulated murine guanylate-binding protein (mGBP) genes was virtually absent in the lungs of LTβR−/− mice.
This demonstrates clearly that the LTβR is essential for the induction of a type II IFN-mediated immune response against T.
gondii.
The pronounced inability to effectively upregulate host defense effector molecules such as GBPs explains the high mortality rates of LTβR−/− animals after T.
gondii infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Behnke, Kristina& Sorg, Ursula R.& Gabbert, Helmut E.& Pfeffer, Klaus. 2017. The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188651
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Behnke, Kristina…[et al.]. The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection. Mediators of Inflammation No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1188651
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Behnke, Kristina& Sorg, Ursula R.& Gabbert, Helmut E.& Pfeffer, Klaus. The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188651
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188651
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر