The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection
Joint Authors
Pfeffer, Klaus
Behnke, Kristina
Sorg, Ursula R.
Gabbert, Helmut E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Lymphotoxin β receptor (LTβR) signaling plays an important role in efficient initiation of host responses to a variety of pathogens, encompassing viruses, bacteria, and protozoans via induction of the type I interferon response.
The present study reveals that after Toxoplasma gondii infection, LTβR−/− mice show a substantially reduced survival rate when compared to wild-type mice.
LTβR−/− mice exhibit an increased parasite load and a more pronounced organ pathology.
Also, a delayed increase of serum IL-12p40 and a failure of the protective IFNγ response in LTβR−/− mice were observed.
Serum NO levels in LTβR−/− animals rose later and were markedly decreased compared to wild-type animals.
At the transcriptional level, LTβR−/− animals exhibited a deregulated expression profile of several cytokines known to play a role in activation of innate immunity in T.
gondii infection.
Importantly, expression of the IFNγ-regulated murine guanylate-binding protein (mGBP) genes was virtually absent in the lungs of LTβR−/− mice.
This demonstrates clearly that the LTβR is essential for the induction of a type II IFN-mediated immune response against T.
gondii.
The pronounced inability to effectively upregulate host defense effector molecules such as GBPs explains the high mortality rates of LTβR−/− animals after T.
gondii infection.
American Psychological Association (APA)
Behnke, Kristina& Sorg, Ursula R.& Gabbert, Helmut E.& Pfeffer, Klaus. 2017. The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188651
Modern Language Association (MLA)
Behnke, Kristina…[et al.]. The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection. Mediators of Inflammation No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1188651
American Medical Association (AMA)
Behnke, Kristina& Sorg, Ursula R.& Gabbert, Helmut E.& Pfeffer, Klaus. The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188651