The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics
المؤلفون المشاركون
Dong, Liang
Ma, Xiaohui
Xu, Jiawei
Liu, Yahui
Liu, Tian
Wu, Jinxiang
Li, Tao
Jiao, Xingai
Zhang, Haiqing
Wang, Junfei
Liu, Lin
Cao, Liuzhao
Li, Shuo
Xu, Jianfeng
Yang, Lei
Zhao, Jiping
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Asthma is characterized by airway remodeling.
Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein.
Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma.
Objectives.
To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma.
Methods.
We examined FSTL1 levels in 32 asthmatics and 25 controls.
All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed.
Additionally, 15 of the 32 asthmatics underwent fibre optic bronchoscopy.
Spearman rank analysis was performed to detect the correlation between FSTL1 and other parameters.
Results.
Plasma FSTL1 levels were higher in asthmatics (130.762 ± 46.029 ng/mL) than in controls (95.408 ± 33.938 ng/mL) (p=0.009).
Plasma FSTL1 levels were associated with fibrosis levels around the airways (rs=0.529, p=0.043) and α-smooth muscle actin (α-SMA) (rs=0.554, p=0.032).
FSTL1 levels in bronchoalveolar lavage fluid were associated with collagen I (rs=0.536, p=0.040), α-SMA (rs=0.561, p=0.029), fibrosis levels (rs=0.779, p=0.001), and the thickness of the airway reticular basement membrane (RBM) (rs=0.660, p=0.007).
Conclusions.
FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM.
FSTL1 may contribute to airway remodeling in asthmatics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yahui& Liu, Tian& Wu, Jinxiang& Li, Tao& Jiao, Xingai& Zhang, Haiqing…[et al.]. 2017. The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188708
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yahui…[et al.]. The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188708
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yahui& Liu, Tian& Wu, Jinxiang& Li, Tao& Jiao, Xingai& Zhang, Haiqing…[et al.]. The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188708
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188708
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر