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The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics
Joint Authors
Dong, Liang
Ma, Xiaohui
Xu, Jiawei
Liu, Yahui
Liu, Tian
Wu, Jinxiang
Li, Tao
Jiao, Xingai
Zhang, Haiqing
Wang, Junfei
Liu, Lin
Cao, Liuzhao
Li, Shuo
Xu, Jianfeng
Yang, Lei
Zhao, Jiping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Asthma is characterized by airway remodeling.
Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein.
Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma.
Objectives.
To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma.
Methods.
We examined FSTL1 levels in 32 asthmatics and 25 controls.
All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed.
Additionally, 15 of the 32 asthmatics underwent fibre optic bronchoscopy.
Spearman rank analysis was performed to detect the correlation between FSTL1 and other parameters.
Results.
Plasma FSTL1 levels were higher in asthmatics (130.762 ± 46.029 ng/mL) than in controls (95.408 ± 33.938 ng/mL) (p=0.009).
Plasma FSTL1 levels were associated with fibrosis levels around the airways (rs=0.529, p=0.043) and α-smooth muscle actin (α-SMA) (rs=0.554, p=0.032).
FSTL1 levels in bronchoalveolar lavage fluid were associated with collagen I (rs=0.536, p=0.040), α-SMA (rs=0.561, p=0.029), fibrosis levels (rs=0.779, p=0.001), and the thickness of the airway reticular basement membrane (RBM) (rs=0.660, p=0.007).
Conclusions.
FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM.
FSTL1 may contribute to airway remodeling in asthmatics.
American Psychological Association (APA)
Liu, Yahui& Liu, Tian& Wu, Jinxiang& Li, Tao& Jiao, Xingai& Zhang, Haiqing…[et al.]. 2017. The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188708
Modern Language Association (MLA)
Liu, Yahui…[et al.]. The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188708
American Medical Association (AMA)
Liu, Yahui& Liu, Tian& Wu, Jinxiang& Li, Tao& Jiao, Xingai& Zhang, Haiqing…[et al.]. The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188708