Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase
المؤلفون المشاركون
Albi, Elisabetta
Cataldi, Samuela
Ferri, Ivana
Ambesi-Impiombato, Francesco Saverio
Beccari, T.
Codini, M.
Siccu, Paola
Sidoni, Angelo
Curcio, Francesco
Traina, Giovanna
Sichetti, Marzia
Loreti, Elisabetta
Gizzi, Chiara
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-11
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified.
In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones.
We have first investigated the changes of thyroid microstructure and the possibility that molecules involved in thyroid function might be associated with structural changes.
Results from this study indicate changes in the height of the thyrocytes and in the amplitude of interfollicular spaces, anomalous expression/localization of thyrotropin, thyrotropin receptor, and thyroglobulin aging.
Thyrotropin and thyrotropin receptor are upregulated and are distributed inside the colloid while thyroglobulin fills the interfollicular spaces.
In an approach aimed at defining the behavior of molecules that change in different physiopathological conditions of thyroid, such as galectin-3 and sphingomyelinase, we then wondered what was their behavior in the thyroid gland in aging.
Importantly, in comparison with the thyroid of young animals, we have found a higher expression of galectin-3 and a delocalization of neutral sphingomyelinase in the thyroid of old animals.
A possible relationship between galectin-3, neutral sphingomyelinase, and aging has been discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Traina, Giovanna& Cataldi, Samuela& Siccu, Paola& Loreti, Elisabetta& Ferri, Ivana& Sidoni, Angelo…[et al.]. 2017. Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1188725
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Traina, Giovanna…[et al.]. Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase. Mediators of Inflammation No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1188725
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Traina, Giovanna& Cataldi, Samuela& Siccu, Paola& Loreti, Elisabetta& Ferri, Ivana& Sidoni, Angelo…[et al.]. Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1188725
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188725
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر