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Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase
Joint Authors
Albi, Elisabetta
Cataldi, Samuela
Ferri, Ivana
Ambesi-Impiombato, Francesco Saverio
Beccari, T.
Codini, M.
Siccu, Paola
Sidoni, Angelo
Curcio, Francesco
Traina, Giovanna
Sichetti, Marzia
Loreti, Elisabetta
Gizzi, Chiara
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified.
In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones.
We have first investigated the changes of thyroid microstructure and the possibility that molecules involved in thyroid function might be associated with structural changes.
Results from this study indicate changes in the height of the thyrocytes and in the amplitude of interfollicular spaces, anomalous expression/localization of thyrotropin, thyrotropin receptor, and thyroglobulin aging.
Thyrotropin and thyrotropin receptor are upregulated and are distributed inside the colloid while thyroglobulin fills the interfollicular spaces.
In an approach aimed at defining the behavior of molecules that change in different physiopathological conditions of thyroid, such as galectin-3 and sphingomyelinase, we then wondered what was their behavior in the thyroid gland in aging.
Importantly, in comparison with the thyroid of young animals, we have found a higher expression of galectin-3 and a delocalization of neutral sphingomyelinase in the thyroid of old animals.
A possible relationship between galectin-3, neutral sphingomyelinase, and aging has been discussed.
American Psychological Association (APA)
Traina, Giovanna& Cataldi, Samuela& Siccu, Paola& Loreti, Elisabetta& Ferri, Ivana& Sidoni, Angelo…[et al.]. 2017. Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1188725
Modern Language Association (MLA)
Traina, Giovanna…[et al.]. Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase. Mediators of Inflammation No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1188725
American Medical Association (AMA)
Traina, Giovanna& Cataldi, Samuela& Siccu, Paola& Loreti, Elisabetta& Ferri, Ivana& Sidoni, Angelo…[et al.]. Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1188725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188725