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The Effect of Rice Bran Extract on Arterial Blood Pressure, Hepatic Steatosis, and Inflammation in Mice Fed with a High-Fat Diet
المؤلفون المشاركون
Duansak, Naphatsanan
Piyabhan, Pritsana
Srisawat, Umarat
Naowaboot, Jarinyaporn
Lerdvuthisopon, Nusiri
Schmid-Schönbein, Geert
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Inflammation and hypertension are primary mechanisms involving in obesity-associated adverse effects of a high-fat diet.
The aim of this study was to evaluate the effects of rice bran extract (RBE) on arterial blood pressure, hepatic steatosis, inflammation, and oxidative stress in high-fat diet (HFD)-induced obese mice.
Methods.
Male ICR mice were divided into four groups, including a normal-diet control group, a high-fat diet (HFD) (60% kcal from fat) group, an HFD group treated with RBE (220 mg/kg/day), and an HFD group treated with 1100 mg/kg/day for eight weeks.
Besides body weight and arterial blood pressure, we determined liver values of total cholesterol, triglyceride, as well as percent body fat, tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), nuclear factor kappa-B (NF-κB), matrix metalloprotease-9 (MMP-9), cyclooxygenase-2 (COX-2), and mRNA endothelial nitric oxide synthase (eNOS).
Results.
The HFD group had increased body weight, increased systolic and diastolic blood pressure, liver total cholesterol, triglyceride, NF-κB, COX-2 and MMP-9 protein levels, and decreased mRNA eNOS in the aorta.
Mice of the HFD group receiving RBE had reduced diastolic blood pressure, as well as significantly decreased liver and serum TNF-α and MDA levels in the liver, and reduced NF-κB levels in both the liver and heart.
Conclusions.
These results demonstrate that RBE decreases diastolic blood pressure, the liver lipid droplet accumulation, liver and myocardial NF-κB, myocardial COX-2 and MMP-9 protein levels, and oxidative stress.
Moreover, RBE may improve endothelial function and may alleviate adverse health effects associated with obesity including obesity-associated hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Duansak, Naphatsanan& Piyabhan, Pritsana& Srisawat, Umarat& Naowaboot, Jarinyaporn& Lerdvuthisopon, Nusiri& Schmid-Schönbein, Geert. 2020. The Effect of Rice Bran Extract on Arterial Blood Pressure, Hepatic Steatosis, and Inflammation in Mice Fed with a High-Fat Diet. Journal of Nutrition and Metabolism،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1188744
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Duansak, Naphatsanan…[et al.]. The Effect of Rice Bran Extract on Arterial Blood Pressure, Hepatic Steatosis, and Inflammation in Mice Fed with a High-Fat Diet. Journal of Nutrition and Metabolism No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1188744
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Duansak, Naphatsanan& Piyabhan, Pritsana& Srisawat, Umarat& Naowaboot, Jarinyaporn& Lerdvuthisopon, Nusiri& Schmid-Schönbein, Geert. The Effect of Rice Bran Extract on Arterial Blood Pressure, Hepatic Steatosis, and Inflammation in Mice Fed with a High-Fat Diet. Journal of Nutrition and Metabolism. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1188744
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188744
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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