Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23IL-17 Pathway
المؤلفون المشاركون
Araujo, Orlei Ribeiro de
Brunialti, Milena Karina Coló
Silva, Dafne Cardoso Bourguignon da
Senerchia, Andreza Almeida
Moraes Costa Carlesse, Fabianne Altruda de
Petrilli, Antonio Sergio
Salomão, Reinaldo
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
The study aimed to describe the kinetics of various cytokines from day 1 to day 14 of the onset of fever in neutropenic children and to evaluate their performances as discriminators of sepsis in the first 24 hours of fever, the possible influence of filgrastim, and the functioning of the IL-23/IL-17 axis.
Methods.
IL-1β, TNF-α, IL-10, IL-12/23p40, IL-21, IL-6, IL-8, IL-17, G-CSF, and GM-CSF were measured in plasma on days 1, 2, 3, 5, and 14 from the onset of fever in 35 patients.
Results.
Thirteen patients (37.1%) developed sepsis.
In mixed models, IL-6, IL-8, IL-10, and G-CSF showed higher estimated means in septic patients (P<0.005), and IL-12/23p40 and IL-17 in nonseptic patients (P<0.05).
On day 1, IL-6, IL-8, and IL-10 appeared upregulated in patients who received filgrastim.
Only IL-6, IL-8, IL-10, and procalcitonin were useful as discriminators of sepsis.
Associating the markers with each other or to a risk assessment model improved performance.
Conclusions.
Cytokines kinetics showed proinflammatory and anti-inflammatory responses similar to what is described in nonneutropenic patients.
IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis.
Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Araujo, Orlei Ribeiro de& Salomão, Reinaldo& Brunialti, Milena Karina Coló& Silva, Dafne Cardoso Bourguignon da& Senerchia, Andreza Almeida& Moraes Costa Carlesse, Fabianne Altruda de…[et al.]. 2017. Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23IL-17 Pathway. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Araujo, Orlei Ribeiro de…[et al.]. Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23IL-17 Pathway. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Araujo, Orlei Ribeiro de& Salomão, Reinaldo& Brunialti, Milena Karina Coló& Silva, Dafne Cardoso Bourguignon da& Senerchia, Andreza Almeida& Moraes Costa Carlesse, Fabianne Altruda de…[et al.]. Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23IL-17 Pathway. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر