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Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23IL-17 Pathway
Joint Authors
Araujo, Orlei Ribeiro de
Brunialti, Milena Karina Coló
Silva, Dafne Cardoso Bourguignon da
Senerchia, Andreza Almeida
Moraes Costa Carlesse, Fabianne Altruda de
Petrilli, Antonio Sergio
Salomão, Reinaldo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The study aimed to describe the kinetics of various cytokines from day 1 to day 14 of the onset of fever in neutropenic children and to evaluate their performances as discriminators of sepsis in the first 24 hours of fever, the possible influence of filgrastim, and the functioning of the IL-23/IL-17 axis.
Methods.
IL-1β, TNF-α, IL-10, IL-12/23p40, IL-21, IL-6, IL-8, IL-17, G-CSF, and GM-CSF were measured in plasma on days 1, 2, 3, 5, and 14 from the onset of fever in 35 patients.
Results.
Thirteen patients (37.1%) developed sepsis.
In mixed models, IL-6, IL-8, IL-10, and G-CSF showed higher estimated means in septic patients (P<0.005), and IL-12/23p40 and IL-17 in nonseptic patients (P<0.05).
On day 1, IL-6, IL-8, and IL-10 appeared upregulated in patients who received filgrastim.
Only IL-6, IL-8, IL-10, and procalcitonin were useful as discriminators of sepsis.
Associating the markers with each other or to a risk assessment model improved performance.
Conclusions.
Cytokines kinetics showed proinflammatory and anti-inflammatory responses similar to what is described in nonneutropenic patients.
IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis.
Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis.
American Psychological Association (APA)
Araujo, Orlei Ribeiro de& Salomão, Reinaldo& Brunialti, Milena Karina Coló& Silva, Dafne Cardoso Bourguignon da& Senerchia, Andreza Almeida& Moraes Costa Carlesse, Fabianne Altruda de…[et al.]. 2017. Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23IL-17 Pathway. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188752
Modern Language Association (MLA)
Araujo, Orlei Ribeiro de…[et al.]. Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23IL-17 Pathway. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188752
American Medical Association (AMA)
Araujo, Orlei Ribeiro de& Salomão, Reinaldo& Brunialti, Milena Karina Coló& Silva, Dafne Cardoso Bourguignon da& Senerchia, Andreza Almeida& Moraes Costa Carlesse, Fabianne Altruda de…[et al.]. Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23IL-17 Pathway. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188752