Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata
المؤلفون المشاركون
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
Figueiredo-Carvalho, Maria Helena Galdino
Ramos, Lívia de Souza
Barbedo, Leonardo Silva
Oliveira, Jean Carlos Almeida de
Santos, André Luis Souza dos
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Candida glabrata is a facultative intracellular opportunistic fungal pathogen in human infections.
Several virulence-associated attributes are involved in its pathogenesis, host-pathogen interactions, modulation of host immune defenses, and regulation of antifungal drug resistance.
This study evaluated the in vitro antifungal susceptibility profile to five antifungal agents, the production of seven hydrolytic enzymes related to virulence, and the relationship between these phenotypes in 91 clinical strains of C.
glabrata.
All C.
glabrata strains were susceptible to flucytosine.
However, some of these strains showed resistance to amphotericin B (9.9%), fluconazole (15.4%), itraconazole (5.5%), or micafungin (15.4%).
Overall, C.
glabrata strains were good producers of catalase, aspartic protease, esterase, phytase, and hemolysin.
However, caseinase and phospholipase in vitro activities were not detected.
Statistically significant correlations were identified between micafungin minimum inhibitory concentration (MIC) and esterase production, between fluconazole and micafungin MIC and hemolytic activity, and between amphotericin B MIC and phytase production.
These results contribute to clarify some of the C.
glabrata mechanisms of pathogenicity.
Moreover, the association between some virulence attributes and the regulation of antifungal resistance encourage the development of new therapeutic strategies involving virulence mechanisms as potential targets for effective antifungal drug development for the treatment of C.
glabrata infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Figueiredo-Carvalho, Maria Helena Galdino& Ramos, Lívia de Souza& Barbedo, Leonardo Silva& Oliveira, Jean Carlos Almeida de& Santos, André Luis Souza dos& Almeida-Paes, Rodrigo…[et al.]. 2017. Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188795
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Figueiredo-Carvalho, Maria Helena Galdino…[et al.]. Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188795
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Figueiredo-Carvalho, Maria Helena Galdino& Ramos, Lívia de Souza& Barbedo, Leonardo Silva& Oliveira, Jean Carlos Almeida de& Santos, André Luis Souza dos& Almeida-Paes, Rodrigo…[et al.]. Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188795
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188795
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر