Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata
Joint Authors
Almeida-Paes, Rodrigo
Zancopé-Oliveira, Rosely Maria
Figueiredo-Carvalho, Maria Helena Galdino
Ramos, Lívia de Souza
Barbedo, Leonardo Silva
Oliveira, Jean Carlos Almeida de
Santos, André Luis Souza dos
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Candida glabrata is a facultative intracellular opportunistic fungal pathogen in human infections.
Several virulence-associated attributes are involved in its pathogenesis, host-pathogen interactions, modulation of host immune defenses, and regulation of antifungal drug resistance.
This study evaluated the in vitro antifungal susceptibility profile to five antifungal agents, the production of seven hydrolytic enzymes related to virulence, and the relationship between these phenotypes in 91 clinical strains of C.
glabrata.
All C.
glabrata strains were susceptible to flucytosine.
However, some of these strains showed resistance to amphotericin B (9.9%), fluconazole (15.4%), itraconazole (5.5%), or micafungin (15.4%).
Overall, C.
glabrata strains were good producers of catalase, aspartic protease, esterase, phytase, and hemolysin.
However, caseinase and phospholipase in vitro activities were not detected.
Statistically significant correlations were identified between micafungin minimum inhibitory concentration (MIC) and esterase production, between fluconazole and micafungin MIC and hemolytic activity, and between amphotericin B MIC and phytase production.
These results contribute to clarify some of the C.
glabrata mechanisms of pathogenicity.
Moreover, the association between some virulence attributes and the regulation of antifungal resistance encourage the development of new therapeutic strategies involving virulence mechanisms as potential targets for effective antifungal drug development for the treatment of C.
glabrata infections.
American Psychological Association (APA)
Figueiredo-Carvalho, Maria Helena Galdino& Ramos, Lívia de Souza& Barbedo, Leonardo Silva& Oliveira, Jean Carlos Almeida de& Santos, André Luis Souza dos& Almeida-Paes, Rodrigo…[et al.]. 2017. Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188795
Modern Language Association (MLA)
Figueiredo-Carvalho, Maria Helena Galdino…[et al.]. Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata. Mediators of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1188795
American Medical Association (AMA)
Figueiredo-Carvalho, Maria Helena Galdino& Ramos, Lívia de Souza& Barbedo, Leonardo Silva& Oliveira, Jean Carlos Almeida de& Santos, André Luis Souza dos& Almeida-Paes, Rodrigo…[et al.]. Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1188795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1188795