The Performance of Immunocytochemistry Staining as Triaging Tests for High-Risk HPV-Positive Women: A 24-Month Prospective Study
المؤلفون المشاركون
Li, Yu-Cong
Zhao, Yu-Qian
Li, Ting-Yuan
Chen, Wen
Liao, Guang-Dong
Wang, Hai-Rui
Lei, Hai-Ke
Guo, Yue
Zhou, Qi
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
It is urgent to develop an accurate approach to improve the predictive performance of hrHPV-based screening.
The aim is to evaluate the performance of p16/Ki-67 and p16/MCM2 staining to triage high-risk human papillomavirus- (hrHPV-) positive women.
Cervical specimens were collected from eligible women and tested for hrHPV genotyping, cytology, p16/Ki-67, and p16/MCM2 staining at baseline.
Women were invited to participate in follow-up screening by cytology and hrHPV testing at 24 months.
Positive women received colposcopy and biopsies.
Histopathological diagnoses were the gold standard.
485 women came back for the follow-up screening.
The positive rate of p16/Ki-67 was 20.2% and of p16/MCM2 was 27.2%.
The positive rates of p16/Ki-67 ( P<0.001) and p16/MCM2 (P=0.021) were increased by the severity of histopathology findings.
Among hrHPV-positive women, the sensitivity, specificity, PPV, and NPV for p16/Ki-67 were 90.9%, 67.0%, 16.5%, and 99.0%, and for p16/MCM2 were 81.8%, 43.1%, 9.4%, and 97.1%.
The sensitivity of cytology for triaging hrHPV-positive women were lower than p16/Ki-67 (P=0.012) and p16/MCM2 (P=0.065).
The cocktail staining did not add sensitivity to p16/Ki-67 or p16/MCM2 staining alone (P>0.05), however, cutting down the specificity of p16/Ki-67 staining alone with statistical significance (67.0% vs.
40.2%, P<0.001).
The risk of CIN2+ within 24 months for hrHPV-positive but triaging negative women at baseline was 0.5 (0.1–2.7), 0.7 (0.1–4.1), and 2.4 (1.1–5.0) for p16/Ki-67, p16/MCM2, and cytology, respectively.
As an objective and accurate immunocytochemical staining, the p16/Ki-67 and p16/MCM2 dual staining performed better than cytology to triage positive hrHPV.
On condition that high-quality cytology is unavailable, immunocytochemical staining by p16/Ki-67 or p16/MCM2 is an option for triaging hrHPV-positive women.
The combination of p16/Ki-67 and p16/MCM2 could not improve the accuracy in detecting CIN2+.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yu-Cong& Zhao, Yu-Qian& Li, Ting-Yuan& Chen, Wen& Liao, Guang-Dong& Wang, Hai-Rui…[et al.]. 2020. The Performance of Immunocytochemistry Staining as Triaging Tests for High-Risk HPV-Positive Women: A 24-Month Prospective Study. Journal of Oncology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189058
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yu-Cong…[et al.]. The Performance of Immunocytochemistry Staining as Triaging Tests for High-Risk HPV-Positive Women: A 24-Month Prospective Study. Journal of Oncology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1189058
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yu-Cong& Zhao, Yu-Qian& Li, Ting-Yuan& Chen, Wen& Liao, Guang-Dong& Wang, Hai-Rui…[et al.]. The Performance of Immunocytochemistry Staining as Triaging Tests for High-Risk HPV-Positive Women: A 24-Month Prospective Study. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1189058
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189058
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر