A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas
المؤلفون المشاركون
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-24
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Aims.
The preferential dependence on glycolysis as a pathway of energy metabolism is a hallmark of cancer cells.
However, the prognostic significance of glycolysis-related genes in head and neck squamous cell carcinoma (HNSCC) remains obscure.
The purpose of this study was to identify glycolysis-related genes of prognostic value in HNSCC.
Results.
Transcriptional and clinical data of 544 HNSCC samples were obtained from The Cancer Genome Atlas (TCGA) dataset.
By gene set enrichment analysis (GSEA) and by employing a univariate and subsequently a stepwise multivariate Cox proportional regression model, eight glycolysis-related genes of prognostic significance in HNSCC (KIF2A, JMJD8, HMMR, STC2, HK1, EXT2, GPR8, and STC1) were identified.
The patients were clustered into two groups (high and low risk) based on the expression of these genes.
High-risk patients had significantly a shorter overall survival than low-risk patients.
Furthermore, a new prognostic indicator based on selected glycolysis-related genes was developed by multivariate Cox analysis that proved to be a better predictor of patient outcome compared to other clinical factors.
Conclusion.
Our findings provide new insights into the role of glycolysis in HNSCC.
The identified genes predict the patient prognosis and might substantially contribute to the development of individualized treatments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yuchao& Yin, Shihua. 2020. A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas. Journal of Oncology،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1189078
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yuchao& Yin, Shihua. A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas. Journal of Oncology No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1189078
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yuchao& Yin, Shihua. A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1189078
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189078
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر