A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aims.
The preferential dependence on glycolysis as a pathway of energy metabolism is a hallmark of cancer cells.
However, the prognostic significance of glycolysis-related genes in head and neck squamous cell carcinoma (HNSCC) remains obscure.
The purpose of this study was to identify glycolysis-related genes of prognostic value in HNSCC.
Results.
Transcriptional and clinical data of 544 HNSCC samples were obtained from The Cancer Genome Atlas (TCGA) dataset.
By gene set enrichment analysis (GSEA) and by employing a univariate and subsequently a stepwise multivariate Cox proportional regression model, eight glycolysis-related genes of prognostic significance in HNSCC (KIF2A, JMJD8, HMMR, STC2, HK1, EXT2, GPR8, and STC1) were identified.
The patients were clustered into two groups (high and low risk) based on the expression of these genes.
High-risk patients had significantly a shorter overall survival than low-risk patients.
Furthermore, a new prognostic indicator based on selected glycolysis-related genes was developed by multivariate Cox analysis that proved to be a better predictor of patient outcome compared to other clinical factors.
Conclusion.
Our findings provide new insights into the role of glycolysis in HNSCC.
The identified genes predict the patient prognosis and might substantially contribute to the development of individualized treatments.
American Psychological Association (APA)
Liu, Yuchao& Yin, Shihua. 2020. A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas. Journal of Oncology،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1189078
Modern Language Association (MLA)
Liu, Yuchao& Yin, Shihua. A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas. Journal of Oncology No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1189078
American Medical Association (AMA)
Liu, Yuchao& Yin, Shihua. A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1189078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189078