Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
المؤلفون المشاركون
Ordovas, Jose M.
Zhou, Bingjie
Ichikawa, Reiko
Parnell, Laurence D.
Noel, Sabrina E.
Zhang, Xiyuan
Bhupathiraju, Shilpa N.
Tucker, Katherine L.
Lai, Chao-Qiang
Smith, Caren E.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the metabolic mechanism underlying this correlation is not understood.
Objective.
Our objective was to examine metabolomic links between SSB intake and obesity to understand metabolic mechanisms.
Design.
We examined the association of plasma metabolomic profiles with SSB intake and obesity risk in 781 participants, aged 45–75 y, in the Boston Puerto Rican Health Study (BPRHS) using generalized linear models, controlling for potential confounding factors.
Based on identified metabolites, we conducted pathway enrichment analysis to identify potential metabolic pathways that link SSB intake and obesity risk.
Variants in genes encoding enzymes known to function in identified metabolic pathways were examined for their interactions with SSB intake on obesity.
Results.
SSB intake was correlated with BMI (β = 0.607, P=0.045).
Among 526 measured metabolites, 86 showed a significant correlation with SSB intake and 148 with BMI (P≤0.05); 28 were correlated with both SSB intake and BMI (P≤0.05).
Pathway enrichment analysis identified the phosphatidylcholine and lysophospholipid pathways as linking SSB intake to obesity, after correction for multiple testing.
Furthermore, 8 of 10 genes functioning in these two pathways showed strong interaction with SSB intake on BMI.
Our results further identified participants who may exhibit an increased risk of obesity when consuming SSB.
Conclusions.
We identified two key metabolic pathways that link SSB intake to obesity, revealing the potential of phosphatidylcholine and lysophospholipid to modulate how SSB intake can increase obesity risk.
The interaction between genetic variants related to these pathways and SSB intake on obesity further supports the mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Bingjie& Ichikawa, Reiko& Parnell, Laurence D.& Noel, Sabrina E.& Zhang, Xiyuan& Bhupathiraju, Shilpa N.…[et al.]. 2020. Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity. Journal of Obesity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1189256
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Bingjie…[et al.]. Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity. Journal of Obesity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1189256
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Bingjie& Ichikawa, Reiko& Parnell, Laurence D.& Noel, Sabrina E.& Zhang, Xiyuan& Bhupathiraju, Shilpa N.…[et al.]. Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity. Journal of Obesity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1189256
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189256
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر