Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
Joint Authors
Ordovas, Jose M.
Zhou, Bingjie
Ichikawa, Reiko
Parnell, Laurence D.
Noel, Sabrina E.
Zhang, Xiyuan
Bhupathiraju, Shilpa N.
Tucker, Katherine L.
Lai, Chao-Qiang
Smith, Caren E.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the metabolic mechanism underlying this correlation is not understood.
Objective.
Our objective was to examine metabolomic links between SSB intake and obesity to understand metabolic mechanisms.
Design.
We examined the association of plasma metabolomic profiles with SSB intake and obesity risk in 781 participants, aged 45–75 y, in the Boston Puerto Rican Health Study (BPRHS) using generalized linear models, controlling for potential confounding factors.
Based on identified metabolites, we conducted pathway enrichment analysis to identify potential metabolic pathways that link SSB intake and obesity risk.
Variants in genes encoding enzymes known to function in identified metabolic pathways were examined for their interactions with SSB intake on obesity.
Results.
SSB intake was correlated with BMI (β = 0.607, P=0.045).
Among 526 measured metabolites, 86 showed a significant correlation with SSB intake and 148 with BMI (P≤0.05); 28 were correlated with both SSB intake and BMI (P≤0.05).
Pathway enrichment analysis identified the phosphatidylcholine and lysophospholipid pathways as linking SSB intake to obesity, after correction for multiple testing.
Furthermore, 8 of 10 genes functioning in these two pathways showed strong interaction with SSB intake on BMI.
Our results further identified participants who may exhibit an increased risk of obesity when consuming SSB.
Conclusions.
We identified two key metabolic pathways that link SSB intake to obesity, revealing the potential of phosphatidylcholine and lysophospholipid to modulate how SSB intake can increase obesity risk.
The interaction between genetic variants related to these pathways and SSB intake on obesity further supports the mechanism.
American Psychological Association (APA)
Zhou, Bingjie& Ichikawa, Reiko& Parnell, Laurence D.& Noel, Sabrina E.& Zhang, Xiyuan& Bhupathiraju, Shilpa N.…[et al.]. 2020. Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity. Journal of Obesity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1189256
Modern Language Association (MLA)
Zhou, Bingjie…[et al.]. Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity. Journal of Obesity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1189256
American Medical Association (AMA)
Zhou, Bingjie& Ichikawa, Reiko& Parnell, Laurence D.& Noel, Sabrina E.& Zhang, Xiyuan& Bhupathiraju, Shilpa N.…[et al.]. Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity. Journal of Obesity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1189256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1189256