Can Toxoplasma gondii Pave the Road for Dementia?

الملخص EN

Dementia is an ominous neurological disease.

Scientists proposed a link between its occurrence and the presence of Toxoplasma gondii (T.

gondii).

The long-term sequels of anti-Toxoplasma premunition, chiefly dominated by TNF-α, on the neurons and their receptors as the insulin-like growth factor-1 receptor (IGF-1R), which is tangled in cognition and synaptic plasticity, are still not clear.

IGF-1R mediates its action via IGF-1, and its depletion is incorporated in the pathogenesis of dementia.

The activated TNF-α signaling pathway induces NF-κβ that may induce or inhibit neurogenesis.

This study speculates the potential impact of anti-Toxoplasma immune response on the expression of IGF-1R in chronic cerebral toxoplasmosis.

The distributive pattern of T.

gondii cysts was studied in association with TNF-α serum levels, the in situ expression of NF-κβ, and IGF-1R in mice using the low virulent ME-49 T.

gondii strain.

There was an elevation of the TNF-α serum level (p value ≤ 0.004) and significant upsurge in NF-κβ whereas IGF-1R was of low abundance (p value < 0.05) compared to the controls.

TNF-α had a strong positive correlation with the intracerebral expression of NF-κβ (r value ≈ 0.943, p value ≈ 0.005) and a strong negative correlation to IGF-1R (r value -0.584 and -0.725 for area% and O.D., respectively).

This activated TNF-α/NF-κβ keeps T.

gondii under control at the expense of IGF-1R expression, depriving neurons of the effect of IGF-1, the receptor’s ligand.

We therefore deduce that T.

gondii immunopathological reaction may be a road paver for developing dementia.