miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κBInflammatory Signaling Pathway

المؤلفون المشاركون

Xie, Bin
Lu, Can
Chen, Chen
Zhou, Jianhua
Deng, Zhenghao

المصدر

Mediators of Inflammation

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-06-17

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الأمراض

الملخص EN

Silica exposure triggers inflammatory response and pulmonary fibrosis that is a severe occupational or environmental lung disease with no effective therapies.

The complicated biological and molecular mechanisms underlying silica-induced lung damages have not yet been fully understood.

miR-135a inhibits inflammation, apoptosis, and cancer cell proliferation.

But the roles of miRNA135a involved in the silica-induced lung damages remain largely unexplored.

We investigated the roles and mechanisms of miR-135a underlying silica-induced pulmonary fibrosis.

The present study showed silica exposure caused the decrease in miR-135a level but the increase in inflammatory mediators.

Transduction of lentivirus expressing miR-135a reduced the level of inflammatory mediators in lung tissues from silica-treated mice and improved pulmonary fibrosis which was consistent with the downregulated α-SMA but enhanced E-cadherin.

Moreover, miR-135a overexpression inhibited p-p65 level in lung tissues.

Overexpression of miR-135a inhibitor strengthened TLR4 protein level and NF-κB activation in BEAS-2B cells.

Injection of PDTC, an inhibitor of NF-κB, further reinforced miR-135a-mediated amelioration of inflammation and pulmonary fibrosis induced by silica.

The collective data indicate miR-135a restrains NF-κB activation probably through targeting TLR4 to alleviate silica-induced inflammatory response and pulmonary fibrosis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xie, Bin& Lu, Can& Chen, Chen& Zhou, Jianhua& Deng, Zhenghao. 2020. miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κBInflammatory Signaling Pathway. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1191484

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xie, Bin…[et al.]. miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κBInflammatory Signaling Pathway. Mediators of Inflammation No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1191484

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xie, Bin& Lu, Can& Chen, Chen& Zhou, Jianhua& Deng, Zhenghao. miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κBInflammatory Signaling Pathway. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1191484

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1191484