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miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κBInflammatory Signaling Pathway
Joint Authors
Xie, Bin
Lu, Can
Chen, Chen
Zhou, Jianhua
Deng, Zhenghao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Silica exposure triggers inflammatory response and pulmonary fibrosis that is a severe occupational or environmental lung disease with no effective therapies.
The complicated biological and molecular mechanisms underlying silica-induced lung damages have not yet been fully understood.
miR-135a inhibits inflammation, apoptosis, and cancer cell proliferation.
But the roles of miRNA135a involved in the silica-induced lung damages remain largely unexplored.
We investigated the roles and mechanisms of miR-135a underlying silica-induced pulmonary fibrosis.
The present study showed silica exposure caused the decrease in miR-135a level but the increase in inflammatory mediators.
Transduction of lentivirus expressing miR-135a reduced the level of inflammatory mediators in lung tissues from silica-treated mice and improved pulmonary fibrosis which was consistent with the downregulated α-SMA but enhanced E-cadherin.
Moreover, miR-135a overexpression inhibited p-p65 level in lung tissues.
Overexpression of miR-135a inhibitor strengthened TLR4 protein level and NF-κB activation in BEAS-2B cells.
Injection of PDTC, an inhibitor of NF-κB, further reinforced miR-135a-mediated amelioration of inflammation and pulmonary fibrosis induced by silica.
The collective data indicate miR-135a restrains NF-κB activation probably through targeting TLR4 to alleviate silica-induced inflammatory response and pulmonary fibrosis.
American Psychological Association (APA)
Xie, Bin& Lu, Can& Chen, Chen& Zhou, Jianhua& Deng, Zhenghao. 2020. miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κBInflammatory Signaling Pathway. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1191484
Modern Language Association (MLA)
Xie, Bin…[et al.]. miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κBInflammatory Signaling Pathway. Mediators of Inflammation No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1191484
American Medical Association (AMA)
Xie, Bin& Lu, Can& Chen, Chen& Zhou, Jianhua& Deng, Zhenghao. miR-135a Alleviates Silica-Induced Pulmonary Fibrosis by Targeting NF-κBInflammatory Signaling Pathway. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1191484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191484