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Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins
المؤلفون المشاركون
Sahebkar, Amirhossein
Jamialahmadi, Tannaz
Pirro, Matteo
Chamani, Sajad
Bianconi, Vanessa
Tasbandi, Aida
Barreto, George E.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Acute inflammation has been described as a reactive dynamic process, promoted by the secretion of proinflammatory mediators, including lipid molecules like leukotrienes and prostaglandins, and counterbalanced by proresolving mediators including omega-3 polyunsaturated fatty-acid- (PUFA-) derived molecules.
The switch from the initiation to the resolution phase of acute inflammatory response is crucial for tissue homeostasis, whereas the failure to resolve early inflammation by specialized proresolving mediators leads to chronic inflammation and tissue damage.
Among PUFA-derived proresolving mediators, different eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derivatives have been described, namely, resolvins (resolution phase interaction products), which exert their anti-inflammatory and immune-regulatory activities through specific G-protein-coupled receptors.
In recent years, compelling evidence has shown that impairment of resolution of inflammation is a crucial pathogenic hallmark in different neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease.
This review summarizes current knowledge on the role of resolvins in resolution of inflammation and highlights available evidence showing the neuroprotective potential of EPA- and DHA-derived resolvins (E-series and D-series resolvins, respectively) in neurodegenerative diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chamani, Sajad& Bianconi, Vanessa& Tasbandi, Aida& Pirro, Matteo& Barreto, George E.& Jamialahmadi, Tannaz…[et al.]. 2020. Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1191646
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chamani, Sajad…[et al.]. Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins. Mediators of Inflammation No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1191646
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chamani, Sajad& Bianconi, Vanessa& Tasbandi, Aida& Pirro, Matteo& Barreto, George E.& Jamialahmadi, Tannaz…[et al.]. Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1191646
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191646
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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