Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins
Joint Authors
Sahebkar, Amirhossein
Jamialahmadi, Tannaz
Pirro, Matteo
Chamani, Sajad
Bianconi, Vanessa
Tasbandi, Aida
Barreto, George E.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acute inflammation has been described as a reactive dynamic process, promoted by the secretion of proinflammatory mediators, including lipid molecules like leukotrienes and prostaglandins, and counterbalanced by proresolving mediators including omega-3 polyunsaturated fatty-acid- (PUFA-) derived molecules.
The switch from the initiation to the resolution phase of acute inflammatory response is crucial for tissue homeostasis, whereas the failure to resolve early inflammation by specialized proresolving mediators leads to chronic inflammation and tissue damage.
Among PUFA-derived proresolving mediators, different eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derivatives have been described, namely, resolvins (resolution phase interaction products), which exert their anti-inflammatory and immune-regulatory activities through specific G-protein-coupled receptors.
In recent years, compelling evidence has shown that impairment of resolution of inflammation is a crucial pathogenic hallmark in different neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease.
This review summarizes current knowledge on the role of resolvins in resolution of inflammation and highlights available evidence showing the neuroprotective potential of EPA- and DHA-derived resolvins (E-series and D-series resolvins, respectively) in neurodegenerative diseases.
American Psychological Association (APA)
Chamani, Sajad& Bianconi, Vanessa& Tasbandi, Aida& Pirro, Matteo& Barreto, George E.& Jamialahmadi, Tannaz…[et al.]. 2020. Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1191646
Modern Language Association (MLA)
Chamani, Sajad…[et al.]. Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins. Mediators of Inflammation No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1191646
American Medical Association (AMA)
Chamani, Sajad& Bianconi, Vanessa& Tasbandi, Aida& Pirro, Matteo& Barreto, George E.& Jamialahmadi, Tannaz…[et al.]. Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1191646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191646