Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism
المؤلفون المشاركون
Corbetta, Sabrina
Corsi Romanelli, Massimiliano M.
Passeri, Elena
Eller-Vainicher, C.
Vianello, E.
Palmieri, S.
Dozio, Elena
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Primary hyperparathyroidism (PHPT) is a common cause of secondary osteoporosis in postmenopausal women.
Th17 lymphocytes and the released cytokine IL-17A play an important role in bone metabolism.
Th17 cells have been shown to be activated by PTH, and peripheral blood T cells from patients affected with PHPT express higher levels of IL-17A mRNA than controls.
Aim.
To investigate circulating levels of IL-17A and the ratio RANKL/OPG, as markers of osteoclastogenesis, in 50 postmenopausal PHPT women compared with postmenopausal osteoporotic non-PHPT women (n=20).
Results.
Circulating levels of IL-17A were similarly detectable in most PHPT and non-PHPT osteoporotic women (12.9 (8.4-23.1) vs.
11.3 (8.3-14.3) pg/ml, median (range interquartile), P=0.759), at variance with premenopausal women where IL-17A was undetectable.
In PHPT women, any significant correlations could be detected between circulating IL-17A levels and PTH levels.
Nonetheless, significant negative correlations between circulating IL-17A and ionized calcium levels (r=‐0.294, P=0.047) and urine calcium excretions (r=‐0.300, P=0.045) were found.
Moreover, PHPT women were characterized by positive correlations between IL-17A levels and femur neck (r=0.364, P=0.021) and total hip (r=0.353, P=0.015) T-scores.
Circulating IL-17A levels did not show any significant correlation with sRANKL, OPG, and sRANKL/OPG ratio in PHPT women.
Conclusions.
In postmenopausal PHPT women, circulating IL-17A levels were similar to those detected in postmenopausal non-PHPT women, showing a disruption of the relationship observed in postmenopausal osteoporosis among circulating PTH, sRANKL, OPG, IL-17A, and bone demineralization in postmenopausal PHPT women.
The data support an osteogenic effect of IL-17A in postmenopausal PHPT women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dozio, Elena& Passeri, Elena& Vianello, E.& Palmieri, S.& Eller-Vainicher, C.& Corsi Romanelli, Massimiliano M.…[et al.]. 2020. Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191663
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dozio, Elena…[et al.]. Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism. Mediators of Inflammation No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1191663
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dozio, Elena& Passeri, Elena& Vianello, E.& Palmieri, S.& Eller-Vainicher, C.& Corsi Romanelli, Massimiliano M.…[et al.]. Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191663
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191663
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر