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Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism
Joint Authors
Corbetta, Sabrina
Corsi Romanelli, Massimiliano M.
Passeri, Elena
Eller-Vainicher, C.
Vianello, E.
Palmieri, S.
Dozio, Elena
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Primary hyperparathyroidism (PHPT) is a common cause of secondary osteoporosis in postmenopausal women.
Th17 lymphocytes and the released cytokine IL-17A play an important role in bone metabolism.
Th17 cells have been shown to be activated by PTH, and peripheral blood T cells from patients affected with PHPT express higher levels of IL-17A mRNA than controls.
Aim.
To investigate circulating levels of IL-17A and the ratio RANKL/OPG, as markers of osteoclastogenesis, in 50 postmenopausal PHPT women compared with postmenopausal osteoporotic non-PHPT women (n=20).
Results.
Circulating levels of IL-17A were similarly detectable in most PHPT and non-PHPT osteoporotic women (12.9 (8.4-23.1) vs.
11.3 (8.3-14.3) pg/ml, median (range interquartile), P=0.759), at variance with premenopausal women where IL-17A was undetectable.
In PHPT women, any significant correlations could be detected between circulating IL-17A levels and PTH levels.
Nonetheless, significant negative correlations between circulating IL-17A and ionized calcium levels (r=‐0.294, P=0.047) and urine calcium excretions (r=‐0.300, P=0.045) were found.
Moreover, PHPT women were characterized by positive correlations between IL-17A levels and femur neck (r=0.364, P=0.021) and total hip (r=0.353, P=0.015) T-scores.
Circulating IL-17A levels did not show any significant correlation with sRANKL, OPG, and sRANKL/OPG ratio in PHPT women.
Conclusions.
In postmenopausal PHPT women, circulating IL-17A levels were similar to those detected in postmenopausal non-PHPT women, showing a disruption of the relationship observed in postmenopausal osteoporosis among circulating PTH, sRANKL, OPG, IL-17A, and bone demineralization in postmenopausal PHPT women.
The data support an osteogenic effect of IL-17A in postmenopausal PHPT women.
American Psychological Association (APA)
Dozio, Elena& Passeri, Elena& Vianello, E.& Palmieri, S.& Eller-Vainicher, C.& Corsi Romanelli, Massimiliano M.…[et al.]. 2020. Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191663
Modern Language Association (MLA)
Dozio, Elena…[et al.]. Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism. Mediators of Inflammation No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1191663
American Medical Association (AMA)
Dozio, Elena& Passeri, Elena& Vianello, E.& Palmieri, S.& Eller-Vainicher, C.& Corsi Romanelli, Massimiliano M.…[et al.]. Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1191663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191663