Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer
المؤلفون المشاركون
Qu, Hua
Zheng, Hongting
Miao, Tian
Huang, Bangliang
He, Niexia
Sun, Lihua
Du, Guangsheng
Gong, Xiaoli
Zheng, Yi
Xu, Yong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters.
Methods.
Plasma MaR1 concentrations were analyzed in 96 subjects with normal glucose tolerant (NC, n=43), type 2 diabetes (T2DM, n=40), or diabetic foot ulcer (DFU, n=13).
The intravenous glucose tolerance test (IVGTT) and biochemical parameters were measured in all participants.
Results.
Plasma MaR1 concentrations were significant decreased in type 2 diabetes patient with or without DFU compared with NC (both P<0.001) and were lowest in DFU patients among these 3 groups.
(DFU vs.
T2DM, P<0.05).
Plasma MaR1 concentrations were negatively correlated with BMI, waist circumference (Wc), waist hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), LDL-c, FPG, 2hPG, HbA1c, and homeostasis model assessment for insulin resistance (HOMA-IR) (all P<0.05) and were positively correlated with HDL-c, acute insulin response (AIR), area under the curve of the first-phase (0-10 min) insulin secretion (AUC), and homeostasis model assessment for beta-cell function (HOMA-β) (all P<0.05).
After adjusting for age and sex, Wc, WHR, TG, FPG, 2hPG, HbA1c, HOMA-IR, AIR, AUC, and HOMA-β remain statistically significant (all P<0.05).
Conclusions.
Plasma MaR1 concentration were decreased in T2DM with or without DFUs and were the lowest in DFU patients.
The decreased plasma MaR1 strongly associated with obesity, impaired glucose and lipid metabolism, reduced first-phase of glucose-stimulated insulin secretion, and enhanced insulin resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miao, Tian& Huang, Bangliang& He, Niexia& Sun, Lihua& Du, Guangsheng& Gong, Xiaoli…[et al.]. 2020. Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191766
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miao, Tian…[et al.]. Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer. Mediators of Inflammation No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1191766
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miao, Tian& Huang, Bangliang& He, Niexia& Sun, Lihua& Du, Guangsheng& Gong, Xiaoli…[et al.]. Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191766
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191766
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر