Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer
Joint Authors
Qu, Hua
Zheng, Hongting
Miao, Tian
Huang, Bangliang
He, Niexia
Sun, Lihua
Du, Guangsheng
Gong, Xiaoli
Zheng, Yi
Xu, Yong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters.
Methods.
Plasma MaR1 concentrations were analyzed in 96 subjects with normal glucose tolerant (NC, n=43), type 2 diabetes (T2DM, n=40), or diabetic foot ulcer (DFU, n=13).
The intravenous glucose tolerance test (IVGTT) and biochemical parameters were measured in all participants.
Results.
Plasma MaR1 concentrations were significant decreased in type 2 diabetes patient with or without DFU compared with NC (both P<0.001) and were lowest in DFU patients among these 3 groups.
(DFU vs.
T2DM, P<0.05).
Plasma MaR1 concentrations were negatively correlated with BMI, waist circumference (Wc), waist hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), LDL-c, FPG, 2hPG, HbA1c, and homeostasis model assessment for insulin resistance (HOMA-IR) (all P<0.05) and were positively correlated with HDL-c, acute insulin response (AIR), area under the curve of the first-phase (0-10 min) insulin secretion (AUC), and homeostasis model assessment for beta-cell function (HOMA-β) (all P<0.05).
After adjusting for age and sex, Wc, WHR, TG, FPG, 2hPG, HbA1c, HOMA-IR, AIR, AUC, and HOMA-β remain statistically significant (all P<0.05).
Conclusions.
Plasma MaR1 concentration were decreased in T2DM with or without DFUs and were the lowest in DFU patients.
The decreased plasma MaR1 strongly associated with obesity, impaired glucose and lipid metabolism, reduced first-phase of glucose-stimulated insulin secretion, and enhanced insulin resistance.
American Psychological Association (APA)
Miao, Tian& Huang, Bangliang& He, Niexia& Sun, Lihua& Du, Guangsheng& Gong, Xiaoli…[et al.]. 2020. Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191766
Modern Language Association (MLA)
Miao, Tian…[et al.]. Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer. Mediators of Inflammation No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1191766
American Medical Association (AMA)
Miao, Tian& Huang, Bangliang& He, Niexia& Sun, Lihua& Du, Guangsheng& Gong, Xiaoli…[et al.]. Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191766