Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study

المؤلفون المشاركون

Dongying, Chen
Li, Weinian
Cai, Xiaoyan
Lao, Minxi
Zhang, Jianyu
Zhan, Yanfeng
Zhan, Zhongping

المصدر

Journal of Immunology Research

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-09-03

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Objective.

To investigate the fetal and maternal outcomes as well as predictors of APOs in women with SLE who conceived when the disease was stable, the so-called “planned pregnancy.” Methods.

A retrospective multicenter study of 243 patients with SLE who underwent a planned pregnancy was performed.

APOs in fetus and mothers were recorded.

Results.

The average age at conception was 28.9 ± 3.9 years.

Duration of SLE prior to pregnancy was 4.4 ± 4.3 years.

Fetal APOs occurred in 86 (86/243, 35.4%) patients.

Preterm births, intrauterine growth retardation (IUGR), fetal distress, and fetal loss accounted for 22.2%, 14.8%, 11.1%, and 4.9%, respectively.

Forty-two preterm infants (42/54, 77.8%) were delivered after the 34th week of gestation.

All the preterm infants were viable.

Fifty-two patients (52/243, 21.4%) had disease flares, among which 45 cases (45/52, 86.5%) were mild, 6 (6/52, 11.5%) were moderate, and 1 (1/52, 1.9%) was severe.

Disease flares were mainly presented as active lupus nephritis (41/52, 78.8%), thrombocytopenia (10/52, 19.2%), and skin/mucosa lesions (9/52, 17.3%).

Pregnancy-induced hypertension (PIH) occurred in 29 patients, among which 3 were gestational hypertension and 26 were preeclampsia.

Multiple analysis showed that disease flares (OR, 8.1; CI, 3.8–17.2) and anticardiolipin antibody positivity (OR, 7.4; CI, 2.5–21.8) were associated with composite fetal APOs.

Conclusion.

Planned pregnancy improved fetal and maternal outcomes, presenting as a lower rate of fetal loss, more favorable outcomes for preterm infants, and less severe disease flares during pregnancy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Dongying, Chen& Lao, Minxi& Zhang, Jianyu& Zhan, Yanfeng& Li, Weinian& Cai, Xiaoyan…[et al.]. 2018. Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191793

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Dongying, Chen…[et al.]. Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1191793

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Dongying, Chen& Lao, Minxi& Zhang, Jianyu& Zhan, Yanfeng& Li, Weinian& Cai, Xiaoyan…[et al.]. Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191793

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1191793