Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study
Joint Authors
Dongying, Chen
Li, Weinian
Cai, Xiaoyan
Lao, Minxi
Zhang, Jianyu
Zhan, Yanfeng
Zhan, Zhongping
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To investigate the fetal and maternal outcomes as well as predictors of APOs in women with SLE who conceived when the disease was stable, the so-called “planned pregnancy.” Methods.
A retrospective multicenter study of 243 patients with SLE who underwent a planned pregnancy was performed.
APOs in fetus and mothers were recorded.
Results.
The average age at conception was 28.9 ± 3.9 years.
Duration of SLE prior to pregnancy was 4.4 ± 4.3 years.
Fetal APOs occurred in 86 (86/243, 35.4%) patients.
Preterm births, intrauterine growth retardation (IUGR), fetal distress, and fetal loss accounted for 22.2%, 14.8%, 11.1%, and 4.9%, respectively.
Forty-two preterm infants (42/54, 77.8%) were delivered after the 34th week of gestation.
All the preterm infants were viable.
Fifty-two patients (52/243, 21.4%) had disease flares, among which 45 cases (45/52, 86.5%) were mild, 6 (6/52, 11.5%) were moderate, and 1 (1/52, 1.9%) was severe.
Disease flares were mainly presented as active lupus nephritis (41/52, 78.8%), thrombocytopenia (10/52, 19.2%), and skin/mucosa lesions (9/52, 17.3%).
Pregnancy-induced hypertension (PIH) occurred in 29 patients, among which 3 were gestational hypertension and 26 were preeclampsia.
Multiple analysis showed that disease flares (OR, 8.1; CI, 3.8–17.2) and anticardiolipin antibody positivity (OR, 7.4; CI, 2.5–21.8) were associated with composite fetal APOs.
Conclusion.
Planned pregnancy improved fetal and maternal outcomes, presenting as a lower rate of fetal loss, more favorable outcomes for preterm infants, and less severe disease flares during pregnancy.
American Psychological Association (APA)
Dongying, Chen& Lao, Minxi& Zhang, Jianyu& Zhan, Yanfeng& Li, Weinian& Cai, Xiaoyan…[et al.]. 2018. Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191793
Modern Language Association (MLA)
Dongying, Chen…[et al.]. Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1191793
American Medical Association (AMA)
Dongying, Chen& Lao, Minxi& Zhang, Jianyu& Zhan, Yanfeng& Li, Weinian& Cai, Xiaoyan…[et al.]. Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191793