![](/images/graphics-bg.png)
Carotenoids Inhibit Fructose-Induced Inflammatory Response in Human Endothelial Cells and Monocytes
المؤلفون المشاركون
Yu, Xiaoting
Lin, Ping
Ren, Qian
Wu, Jiali
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
This research is aimed at determining the vascular health characteristics of carotenoids by evaluating their effect on excessive inflammatory response in endothelial and monocyte cells, the main factors of atherosclerosis.
Methods.
Human umbilical vein endothelial cells (HUVECs) or U937 monocytes were treated with escalating concentrations (0.1, 0.5, and 1 μM) of five most common carotenoids in human plasma, i.e., α-carotene, β-carotene, β-cryptoxanthin, lutein, and lycopene prior to stimulation with 2 mM fructose.
We examined the monocyte adhesion to endothelial cells (ECs) and relevant endothelial adhesion molecules.
Chemokine and proinflammatory cytokine production as well as intracellular oxidative stress were also assessed in fructose-stimulated ECs and monocytes.
Results.
Carotenoids repressed monocyte adhesion to fructose-stimulated ECs dose dependently via decreasing primarily the expression of endothelial VCAM-1.
In ECs and monocytes, three carotenoids, i.e., β-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-α and IL-1β, with CXCL-10 being the most repressed inflammatory mediator.
β-Cryptoxanthin, lutein, and lycopene dramatically downregulated the fructose-induced CXCL-10 expression in vascular cells.
The reduction in the inflammatory response was associated with a slight but significant decrease of intracellular oxidative stress.
Conclusions.
Our results show that carotenoids have a variety of anti-inflammatory and antiatherosclerosis activities, which can help prevent or reduce fructose-induced inflammatory vascular diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Ping& Ren, Qian& Yu, Xiaoting& Wu, Jiali. 2020. Carotenoids Inhibit Fructose-Induced Inflammatory Response in Human Endothelial Cells and Monocytes. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191816
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Ping…[et al.]. Carotenoids Inhibit Fructose-Induced Inflammatory Response in Human Endothelial Cells and Monocytes. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1191816
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Ping& Ren, Qian& Yu, Xiaoting& Wu, Jiali. Carotenoids Inhibit Fructose-Induced Inflammatory Response in Human Endothelial Cells and Monocytes. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191816
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191816
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)