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The Role of MonocyteMacrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation
المؤلفون المشاركون
Gomaa, Asmaa Ibrahim
Ehsan, Nermine Ahmed
Elrefaei, Ahmed A.
Sultan, Mervat Mohamed
Elsabaawy, Maha Mohamed
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV.
The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are managed differently.
Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury.
The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation.
Methods.
Twenty-nine cases of recurrent hepatitis C and 26 cases of ACR were included in this study.
The expression of CD 68 (macrophage marker), CD11b (BDM marker), and CxCR3 in the postliver transplant biopsy using immunohistochemistry was determined.
Results.
CD11b expression highlighting macrophages of BDM origin was in favor of recurrent hepatitis C (P<0.001) than in ACR (P=0.44), while CXCR3 expression by hepatocytes was in favor of ACR (P=0.001).
Conclusion.
Macrophage infiltrating liver tissue post LT can distinguish between ACR by upregulation of CXCR3 and recurrent hepatitis C by predominant CD11b.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gomaa, Asmaa Ibrahim& Ehsan, Nermine Ahmed& Elrefaei, Ahmed A.& Sultan, Mervat Mohamed& Elsabaawy, Maha Mohamed. 2018. The Role of MonocyteMacrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191946
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gomaa, Asmaa Ibrahim…[et al.]. The Role of MonocyteMacrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1191946
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gomaa, Asmaa Ibrahim& Ehsan, Nermine Ahmed& Elrefaei, Ahmed A.& Sultan, Mervat Mohamed& Elsabaawy, Maha Mohamed. The Role of MonocyteMacrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191946
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191946
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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