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The Role of MonocyteMacrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation
Joint Authors
Gomaa, Asmaa Ibrahim
Ehsan, Nermine Ahmed
Elrefaei, Ahmed A.
Sultan, Mervat Mohamed
Elsabaawy, Maha Mohamed
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV.
The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are managed differently.
Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury.
The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation.
Methods.
Twenty-nine cases of recurrent hepatitis C and 26 cases of ACR were included in this study.
The expression of CD 68 (macrophage marker), CD11b (BDM marker), and CxCR3 in the postliver transplant biopsy using immunohistochemistry was determined.
Results.
CD11b expression highlighting macrophages of BDM origin was in favor of recurrent hepatitis C (P<0.001) than in ACR (P=0.44), while CXCR3 expression by hepatocytes was in favor of ACR (P=0.001).
Conclusion.
Macrophage infiltrating liver tissue post LT can distinguish between ACR by upregulation of CXCR3 and recurrent hepatitis C by predominant CD11b.
American Psychological Association (APA)
Gomaa, Asmaa Ibrahim& Ehsan, Nermine Ahmed& Elrefaei, Ahmed A.& Sultan, Mervat Mohamed& Elsabaawy, Maha Mohamed. 2018. The Role of MonocyteMacrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191946
Modern Language Association (MLA)
Gomaa, Asmaa Ibrahim…[et al.]. The Role of MonocyteMacrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1191946
American Medical Association (AMA)
Gomaa, Asmaa Ibrahim& Ehsan, Nermine Ahmed& Elrefaei, Ahmed A.& Sultan, Mervat Mohamed& Elsabaawy, Maha Mohamed. The Role of MonocyteMacrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1191946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191946