Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients
المؤلفون المشاركون
Aekplakorn, Wichai
Puangpetch, Apichaya
Sukasem, Chonlaphat
Chularojanamontri, Leena
Tuchinda, Papapit
Chaichan, Chonlawat
Nakkrut, Thapanat
Satapornpong, Patompong
Jaruthamsophon, Kanoot
Jantararoungtong, Thawinee
Koomdee, Napatrupron
Sririttha, Suthida
Medhasi, Sadeep
Oo-Puthinan, Sarawut
Rerkpattanapipat, Ticha
Klaewsongkram, Jettanong
Rerknimitr, Pawinee
Tovanabutra, Napatra
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients.
The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported.
The aim of the present study was to carry out an analysis of the involvement of HLA-B alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population.
A case-control study was performed by genotyping the HLA-B alleles of Thai carbamazepine-induced hypersensitivity reaction patients (17 MPE, 16 SJS/TEN, and 5 DRESS) and 271 carbamazepine-tolerant controls.
We also recruited 470 healthy Thai candidate subjects who had not taken carbamazepine.
HLA-B∗15:02 showed a significant association with carbamazepine-induced MPE (P=0.0022, odds ratio (OR) (95% confidence interval [CI]) = 7.27 (2.04–25.97)) and carbamazepine-induced SJS/TEN (P=4.46×10−13; OR (95% CI) = 70.91(19.67–255.65)) when compared with carbamazepine-tolerant controls.
Carbamazepine-induced SJS/TEN also showed an association with HLA-B∗15:21 allele (P=0.013; OR (95% CI) = 9.54 (1.61–56.57)) when compared with carbamazepine-tolerant controls.
HLA-B∗58:01 allele was significantly related to carbamazepine-induced MPE (P=0.007; OR (95% CI) = 4.73 (1.53–14.66)) and DRESS (P=0.0315; OR (95% CI) = 7.55 (1.20–47.58)) when compared with carbamazepine-tolerant controls.
These alleles may serve as markers to predict carbamazepine-induced cADRs in the Thai population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sukasem, Chonlaphat& Chaichan, Chonlawat& Nakkrut, Thapanat& Satapornpong, Patompong& Jaruthamsophon, Kanoot& Jantararoungtong, Thawinee…[et al.]. 2018. Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1191961
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sukasem, Chonlaphat…[et al.]. Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1191961
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sukasem, Chonlaphat& Chaichan, Chonlawat& Nakkrut, Thapanat& Satapornpong, Patompong& Jaruthamsophon, Kanoot& Jantararoungtong, Thawinee…[et al.]. Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1191961
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191961
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر