Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients
Joint Authors
Aekplakorn, Wichai
Puangpetch, Apichaya
Sukasem, Chonlaphat
Chularojanamontri, Leena
Tuchinda, Papapit
Chaichan, Chonlawat
Nakkrut, Thapanat
Satapornpong, Patompong
Jaruthamsophon, Kanoot
Jantararoungtong, Thawinee
Koomdee, Napatrupron
Sririttha, Suthida
Medhasi, Sadeep
Oo-Puthinan, Sarawut
Rerkpattanapipat, Ticha
Klaewsongkram, Jettanong
Rerknimitr, Pawinee
Tovanabutra, Napatra
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients.
The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported.
The aim of the present study was to carry out an analysis of the involvement of HLA-B alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population.
A case-control study was performed by genotyping the HLA-B alleles of Thai carbamazepine-induced hypersensitivity reaction patients (17 MPE, 16 SJS/TEN, and 5 DRESS) and 271 carbamazepine-tolerant controls.
We also recruited 470 healthy Thai candidate subjects who had not taken carbamazepine.
HLA-B∗15:02 showed a significant association with carbamazepine-induced MPE (P=0.0022, odds ratio (OR) (95% confidence interval [CI]) = 7.27 (2.04–25.97)) and carbamazepine-induced SJS/TEN (P=4.46×10−13; OR (95% CI) = 70.91(19.67–255.65)) when compared with carbamazepine-tolerant controls.
Carbamazepine-induced SJS/TEN also showed an association with HLA-B∗15:21 allele (P=0.013; OR (95% CI) = 9.54 (1.61–56.57)) when compared with carbamazepine-tolerant controls.
HLA-B∗58:01 allele was significantly related to carbamazepine-induced MPE (P=0.007; OR (95% CI) = 4.73 (1.53–14.66)) and DRESS (P=0.0315; OR (95% CI) = 7.55 (1.20–47.58)) when compared with carbamazepine-tolerant controls.
These alleles may serve as markers to predict carbamazepine-induced cADRs in the Thai population.
American Psychological Association (APA)
Sukasem, Chonlaphat& Chaichan, Chonlawat& Nakkrut, Thapanat& Satapornpong, Patompong& Jaruthamsophon, Kanoot& Jantararoungtong, Thawinee…[et al.]. 2018. Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1191961
Modern Language Association (MLA)
Sukasem, Chonlaphat…[et al.]. Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1191961
American Medical Association (AMA)
Sukasem, Chonlaphat& Chaichan, Chonlawat& Nakkrut, Thapanat& Satapornpong, Patompong& Jaruthamsophon, Kanoot& Jantararoungtong, Thawinee…[et al.]. Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1191961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191961