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Association of C1qTNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease
المؤلفون المشاركون
Du, Yun-Hui
Wang, Xiao
Nie, Shaoping
Li, Zexuan
Jia, Lixin
Fan, Jingyao
Guo, Ruifeng
Wei, Yongxiang
Ma, Xin L.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Obstructive sleep apnea (OSA) is closely related to the incidence and progression of coronary artery disease (CAD), and the mechanisms linking OSA and CAD are multifactorial.
C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling.
We aimed to ascertain the clinical relevance of CTRP9 with OSA prevalence in patients with CAD.
Methods.
From August 2016 to March 2019, consecutive eligible patients with CAD (n=154; angina pectoris, n=88; acute myocardial infarction [AMI], n=66) underwent cardiorespiratory polygraphy.
OSA was defined as an apnea-hypopnea index (AHI) ≥15 events·h−1.
Plasma CTRP9 concentrations were measured by ELISA method.
Results.
Moderate/severe OSA was present in 89 patients (57.8%).
CTRP9 levels were significantly decreased in the moderate/severe OSA group than in the no/mild OSA group (4.7 [4.1-5.2] ng/mL vs.
4.9 [4.4-6.0] ng/mL, P=0.003).
The difference between groups was only observed in patients with AMI (3.0 [2.3-4.9] vs.
4.5 [3.2-7.9], P=0.009).
Correlation analysis showed that CTRP9 levels were negatively correlated with AHI (r=−0.238, P=0.003) and oxygen desaturation index (r=−0.234, P=0.004) and positively correlated with left ventricular ejection fraction (r=0.251, P=0.004) in all subjects.
Multivariate analysis showed that male gender (OR 3.099, 95% CI 1.029-9.330, P=0.044), BMI (OR 1.148, 95% CI 1.040-1.268, P=0.006), and CTRP9 levels (OR 0.726, 95% CI 0.592-0.890, P=0.002) were independently associated with the prevalence of moderate/severe OSA.
Conclusions.
Plasma CTRP9 levels were independently related to the prevalence of moderate/severe OSA in patients with CAD, suggesting that CTRP9 might play a role in the pathogenesis of CAD exacerbated by OSA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Zexuan& Du, Yun-Hui& Jia, Lixin& Fan, Jingyao& Guo, Ruifeng& Ma, Xin L.…[et al.]. 2020. Association of C1qTNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191963
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Zexuan…[et al.]. Association of C1qTNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1191963
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Zexuan& Du, Yun-Hui& Jia, Lixin& Fan, Jingyao& Guo, Ruifeng& Ma, Xin L.…[et al.]. Association of C1qTNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191963
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191963
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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