Association of C1qTNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease
Joint Authors
Du, Yun-Hui
Wang, Xiao
Nie, Shaoping
Li, Zexuan
Jia, Lixin
Fan, Jingyao
Guo, Ruifeng
Wei, Yongxiang
Ma, Xin L.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Obstructive sleep apnea (OSA) is closely related to the incidence and progression of coronary artery disease (CAD), and the mechanisms linking OSA and CAD are multifactorial.
C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling.
We aimed to ascertain the clinical relevance of CTRP9 with OSA prevalence in patients with CAD.
Methods.
From August 2016 to March 2019, consecutive eligible patients with CAD (n=154; angina pectoris, n=88; acute myocardial infarction [AMI], n=66) underwent cardiorespiratory polygraphy.
OSA was defined as an apnea-hypopnea index (AHI) ≥15 events·h−1.
Plasma CTRP9 concentrations were measured by ELISA method.
Results.
Moderate/severe OSA was present in 89 patients (57.8%).
CTRP9 levels were significantly decreased in the moderate/severe OSA group than in the no/mild OSA group (4.7 [4.1-5.2] ng/mL vs.
4.9 [4.4-6.0] ng/mL, P=0.003).
The difference between groups was only observed in patients with AMI (3.0 [2.3-4.9] vs.
4.5 [3.2-7.9], P=0.009).
Correlation analysis showed that CTRP9 levels were negatively correlated with AHI (r=−0.238, P=0.003) and oxygen desaturation index (r=−0.234, P=0.004) and positively correlated with left ventricular ejection fraction (r=0.251, P=0.004) in all subjects.
Multivariate analysis showed that male gender (OR 3.099, 95% CI 1.029-9.330, P=0.044), BMI (OR 1.148, 95% CI 1.040-1.268, P=0.006), and CTRP9 levels (OR 0.726, 95% CI 0.592-0.890, P=0.002) were independently associated with the prevalence of moderate/severe OSA.
Conclusions.
Plasma CTRP9 levels were independently related to the prevalence of moderate/severe OSA in patients with CAD, suggesting that CTRP9 might play a role in the pathogenesis of CAD exacerbated by OSA.
American Psychological Association (APA)
Li, Zexuan& Du, Yun-Hui& Jia, Lixin& Fan, Jingyao& Guo, Ruifeng& Ma, Xin L.…[et al.]. 2020. Association of C1qTNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191963
Modern Language Association (MLA)
Li, Zexuan…[et al.]. Association of C1qTNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1191963
American Medical Association (AMA)
Li, Zexuan& Du, Yun-Hui& Jia, Lixin& Fan, Jingyao& Guo, Ruifeng& Ma, Xin L.…[et al.]. Association of C1qTNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191963