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miR-24-3pFGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression
المؤلفون المشاركون
Jing, Pengyu
Xie, Nianlin
Zhao, Nan
Gu, Zhongping
Ye, Mingxiang
Zhang, Yong
Zhang, Zhipei
Li, Mengyang
Lai, Xiaofeng
Zhang, Jian
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-05
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Our previous studies showed that Fibroblast growth factor receptor 3 (FGFR3) contributed to cell growth in lung cancer.
However, the correlation between FGFR3 and tumor progression, coupled with the underlying mechanisms, are not fully understood.
The clinical significance of FGFR3 was determined in two cohorts of clinical samples (n=22, n=78).
A panel of biochemical assays and functional experiments was utilized to elucidate the underlying mechanisms and effects of FGFR3 and miR-24-3p on lung adenocarcinoma progression.
Upregulated FGFR3 expression indicated an adverse prognosis for lung adenocarcinoma individuals and promoted metastatic potential of lung adenocarcinoma cells.
Owing to the direct regulation towards FGFR3, miR-24-3p could interfere with the potential of proliferation, migration, and invasion in lung adenocarcinoma, following variations of EMT-related protein expression.
As a significant marker of EMT, E-cadherin was negatively correlated with FGFR3, of which ectopic overexpression could neutralize the antitumour effects of miR-24-3p and reverse its regulatory effects on EMT markers.
Taken together, these findings define a novel insight into the miR-24-3p/FGFR3 signaling axis in regulating lung adenocarcinoma progression and suggest that targeting the miR-24-3p/FGFR3 axis could be an effective and efficient way to prevent tumor progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jing, Pengyu& Zhao, Nan& Xie, Nianlin& Ye, Mingxiang& Zhang, Yong& Zhang, Zhipei…[et al.]. 2018. miR-24-3pFGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1191974
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jing, Pengyu…[et al.]. miR-24-3pFGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression. Journal of Immunology Research No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1191974
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jing, Pengyu& Zhao, Nan& Xie, Nianlin& Ye, Mingxiang& Zhang, Yong& Zhang, Zhipei…[et al.]. miR-24-3pFGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1191974
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191974
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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