miR-24-3pFGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression
Joint Authors
Jing, Pengyu
Xie, Nianlin
Zhao, Nan
Gu, Zhongping
Ye, Mingxiang
Zhang, Yong
Zhang, Zhipei
Li, Mengyang
Lai, Xiaofeng
Zhang, Jian
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Our previous studies showed that Fibroblast growth factor receptor 3 (FGFR3) contributed to cell growth in lung cancer.
However, the correlation between FGFR3 and tumor progression, coupled with the underlying mechanisms, are not fully understood.
The clinical significance of FGFR3 was determined in two cohorts of clinical samples (n=22, n=78).
A panel of biochemical assays and functional experiments was utilized to elucidate the underlying mechanisms and effects of FGFR3 and miR-24-3p on lung adenocarcinoma progression.
Upregulated FGFR3 expression indicated an adverse prognosis for lung adenocarcinoma individuals and promoted metastatic potential of lung adenocarcinoma cells.
Owing to the direct regulation towards FGFR3, miR-24-3p could interfere with the potential of proliferation, migration, and invasion in lung adenocarcinoma, following variations of EMT-related protein expression.
As a significant marker of EMT, E-cadherin was negatively correlated with FGFR3, of which ectopic overexpression could neutralize the antitumour effects of miR-24-3p and reverse its regulatory effects on EMT markers.
Taken together, these findings define a novel insight into the miR-24-3p/FGFR3 signaling axis in regulating lung adenocarcinoma progression and suggest that targeting the miR-24-3p/FGFR3 axis could be an effective and efficient way to prevent tumor progression.
American Psychological Association (APA)
Jing, Pengyu& Zhao, Nan& Xie, Nianlin& Ye, Mingxiang& Zhang, Yong& Zhang, Zhipei…[et al.]. 2018. miR-24-3pFGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1191974
Modern Language Association (MLA)
Jing, Pengyu…[et al.]. miR-24-3pFGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression. Journal of Immunology Research No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1191974
American Medical Association (AMA)
Jing, Pengyu& Zhao, Nan& Xie, Nianlin& Ye, Mingxiang& Zhang, Yong& Zhang, Zhipei…[et al.]. miR-24-3pFGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1191974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191974