Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression
المؤلفون المشاركون
Fang, Yi-Jen
Chung, Yun-Lung
Lin, Cheng-Li
Tien, Ni
Wu, Tien-Yuan
Su, Chih-Yang
Li, Jia-Rong
Lim, Yun-Ping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-16
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Patients with gout are at a higher risk of cardiovascular disease, which is associated with hyperlipidemia.
Management of gout in Taiwan is poor, and the association between urate-lowering therapy (ULT) among gout patients and hyperlipidemia is unclear.
We conducted a retrospective cohort study using data from the Longitudinal Health Insurance Database (LHID) of Taiwan on new-onset gout patients and a comparison cohort without gout.
A Cox proportional hazards model was used to analyze differences in the risk of hyperlipidemia between patients with and without gout after considering related comorbidities.
We also examined the ULT medications on the hepatic expression of lipogenesis-related genes.
After adjusting for potential confounders, the case group (44,413 patients) was found to have a higher risk of hyperlipidemia than the control cohort (177,652 patients) [adjusted hazards ratio aHR=2.55].
Gout patients without antigout treatment had significantly higher risk of hyperlipidemia than the control cohort (aHR=3.10).
Among gout patients receiving ULT, except those receiving probenecid (aHR=0.80), all had significantly lower risk of hyperlipidemia than gout patients without ULT (all aHR<0.90).
Using real-time polymerase chain reaction, we found that most of the antigout drugs decreased the expression of hepatic genes related to lipogenesis in differentiated HepaRG cells.
These data indicate that these antigout drugs reduce hyperlipidemia in gout patients, partly via the reduction in expression of lipogenesis-related genes, leading to improved blood lipid profiles.
We provide evidence of the strong association between gout and hyperlipidemia and highlight the need for appropriate treatment guidelines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fang, Yi-Jen& Wu, Tien-Yuan& Lin, Cheng-Li& Su, Chih-Yang& Li, Jia-Rong& Chung, Yun-Lung…[et al.]. 2020. Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1192173
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fang, Yi-Jen…[et al.]. Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression. Mediators of Inflammation No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1192173
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fang, Yi-Jen& Wu, Tien-Yuan& Lin, Cheng-Li& Su, Chih-Yang& Li, Jia-Rong& Chung, Yun-Lung…[et al.]. Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1192173
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192173
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر