Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression
Joint Authors
Fang, Yi-Jen
Chung, Yun-Lung
Lin, Cheng-Li
Tien, Ni
Wu, Tien-Yuan
Su, Chih-Yang
Li, Jia-Rong
Lim, Yun-Ping
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Patients with gout are at a higher risk of cardiovascular disease, which is associated with hyperlipidemia.
Management of gout in Taiwan is poor, and the association between urate-lowering therapy (ULT) among gout patients and hyperlipidemia is unclear.
We conducted a retrospective cohort study using data from the Longitudinal Health Insurance Database (LHID) of Taiwan on new-onset gout patients and a comparison cohort without gout.
A Cox proportional hazards model was used to analyze differences in the risk of hyperlipidemia between patients with and without gout after considering related comorbidities.
We also examined the ULT medications on the hepatic expression of lipogenesis-related genes.
After adjusting for potential confounders, the case group (44,413 patients) was found to have a higher risk of hyperlipidemia than the control cohort (177,652 patients) [adjusted hazards ratio aHR=2.55].
Gout patients without antigout treatment had significantly higher risk of hyperlipidemia than the control cohort (aHR=3.10).
Among gout patients receiving ULT, except those receiving probenecid (aHR=0.80), all had significantly lower risk of hyperlipidemia than gout patients without ULT (all aHR<0.90).
Using real-time polymerase chain reaction, we found that most of the antigout drugs decreased the expression of hepatic genes related to lipogenesis in differentiated HepaRG cells.
These data indicate that these antigout drugs reduce hyperlipidemia in gout patients, partly via the reduction in expression of lipogenesis-related genes, leading to improved blood lipid profiles.
We provide evidence of the strong association between gout and hyperlipidemia and highlight the need for appropriate treatment guidelines.
American Psychological Association (APA)
Fang, Yi-Jen& Wu, Tien-Yuan& Lin, Cheng-Li& Su, Chih-Yang& Li, Jia-Rong& Chung, Yun-Lung…[et al.]. 2020. Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1192173
Modern Language Association (MLA)
Fang, Yi-Jen…[et al.]. Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression. Mediators of Inflammation No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1192173
American Medical Association (AMA)
Fang, Yi-Jen& Wu, Tien-Yuan& Lin, Cheng-Li& Su, Chih-Yang& Li, Jia-Rong& Chung, Yun-Lung…[et al.]. Effects of Urate-Lowering Therapy on Risk of Hyperlipidemia in Gout by a Population-Based Cohort Study and on In Vitro Hepatic Lipogenesis-Related Gene Expression. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1192173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192173