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STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone
المؤلفون المشاركون
Xu, Liyan
Li, Enmin
Chen, Shuxin
Shen, Huiyang
Liu, Chunpeng
Qiu, Xueli
Zhang, Yufeng
Zhong, Zhigang
Wu, Bingli
Du, Zepeng
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT).
The aim of this study is to use a large cohort study to confirm the involvement of these four genes in GCT recurrence.
Methods.
The expression of these four genes was detected and compared between GCT patients with or without recurrence.
The correlation between the expression of these four genes and clinical characteristics was evaluated.
Protein-protein interaction (PPI) network was constructed for functional enrichment analysis.
Results.
It showed that the expression levels of MDM2, IGF1, STAT1, and RAC1 in GCT patients with recurrence were significantly higher than those in GCT patients without recurrence (P<0.05).
Multivariate logistic regression analysis suggested that several clinical characteristics may influence prognosis.
A PPI network was constructed using the four genes as hub genes.
Functional enrichment analysis showed that this network involves many important biological progress mediated by these four genes, including immune response.
Conclusion.
MDM2, IGF1, STAT1, and RAC1 are associated with GCT recurrence, which might serve as biomarkers for GCT recurrence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Shuxin& Du, Zepeng& Wu, Bingli& Shen, Huiyang& Liu, Chunpeng& Qiu, Xueli…[et al.]. 2018. STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Shuxin…[et al.]. STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Shuxin& Du, Zepeng& Wu, Bingli& Shen, Huiyang& Liu, Chunpeng& Qiu, Xueli…[et al.]. STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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