STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone
Joint Authors
Xu, Liyan
Li, Enmin
Chen, Shuxin
Shen, Huiyang
Liu, Chunpeng
Qiu, Xueli
Zhang, Yufeng
Zhong, Zhigang
Wu, Bingli
Du, Zepeng
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT).
The aim of this study is to use a large cohort study to confirm the involvement of these four genes in GCT recurrence.
Methods.
The expression of these four genes was detected and compared between GCT patients with or without recurrence.
The correlation between the expression of these four genes and clinical characteristics was evaluated.
Protein-protein interaction (PPI) network was constructed for functional enrichment analysis.
Results.
It showed that the expression levels of MDM2, IGF1, STAT1, and RAC1 in GCT patients with recurrence were significantly higher than those in GCT patients without recurrence (P<0.05).
Multivariate logistic regression analysis suggested that several clinical characteristics may influence prognosis.
A PPI network was constructed using the four genes as hub genes.
Functional enrichment analysis showed that this network involves many important biological progress mediated by these four genes, including immune response.
Conclusion.
MDM2, IGF1, STAT1, and RAC1 are associated with GCT recurrence, which might serve as biomarkers for GCT recurrence.
American Psychological Association (APA)
Chen, Shuxin& Du, Zepeng& Wu, Bingli& Shen, Huiyang& Liu, Chunpeng& Qiu, Xueli…[et al.]. 2018. STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192344
Modern Language Association (MLA)
Chen, Shuxin…[et al.]. STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192344
American Medical Association (AMA)
Chen, Shuxin& Du, Zepeng& Wu, Bingli& Shen, Huiyang& Liu, Chunpeng& Qiu, Xueli…[et al.]. STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192344