The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice
المؤلفون المشاركون
He, Xiaojuan
Qiu, Xuemei
Liu, Xue
Shu, Jun
Li, Hong
Zhou, Tongliang
Wang, Ping
Huang, Xiaojie
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS).
Currently, there is still lack of curative treatment for MS.
Mesenchymal stem cell- (MSC-) based therapy is recently the subject of intense interest in autoimmune diseases.
Here, we investigated the therapeutic effect and potential mechanism of human amnion mesenchymal cells (hAMC) on inflammation and remyelination in experimental autoimmune encephalomyelitis (EAE) mice.
C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide.
hAMC were injected intraperitoneal when EAE was successfully established.
The results demonstrated that application of hAMC significantly ameliorated the disease severity and histopathological changes in EAE mice.
The production of proinflammatory cytokines such as IFN-γ, TNF-α, IL-1β, and IL-17A in the spleen and CNS was dramatically inhibited.
Moreover, CD4+ T cells and CD8+ T cells in the CNS were also significantly decreased in EAE mice after hAMC treatment.
In addition, hAMC treatment also promoted the production of neuron-repair factors (NGF, CNTF, and BDNF) in the CNS of EAE mice.
In conclusion, these results indicated that hAMC could attenuate the inflammation and promote the remyelination in EAE mice, which might be a promising cell source for the therapy of MS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shu, Jun& He, Xiaojuan& Li, Hong& Liu, Xue& Qiu, Xuemei& Zhou, Tongliang…[et al.]. 2018. The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shu, Jun…[et al.]. The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shu, Jun& He, Xiaojuan& Li, Hong& Liu, Xue& Qiu, Xuemei& Zhou, Tongliang…[et al.]. The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر