The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice
Joint Authors
He, Xiaojuan
Qiu, Xuemei
Liu, Xue
Shu, Jun
Li, Hong
Zhou, Tongliang
Wang, Ping
Huang, Xiaojie
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS).
Currently, there is still lack of curative treatment for MS.
Mesenchymal stem cell- (MSC-) based therapy is recently the subject of intense interest in autoimmune diseases.
Here, we investigated the therapeutic effect and potential mechanism of human amnion mesenchymal cells (hAMC) on inflammation and remyelination in experimental autoimmune encephalomyelitis (EAE) mice.
C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide.
hAMC were injected intraperitoneal when EAE was successfully established.
The results demonstrated that application of hAMC significantly ameliorated the disease severity and histopathological changes in EAE mice.
The production of proinflammatory cytokines such as IFN-γ, TNF-α, IL-1β, and IL-17A in the spleen and CNS was dramatically inhibited.
Moreover, CD4+ T cells and CD8+ T cells in the CNS were also significantly decreased in EAE mice after hAMC treatment.
In addition, hAMC treatment also promoted the production of neuron-repair factors (NGF, CNTF, and BDNF) in the CNS of EAE mice.
In conclusion, these results indicated that hAMC could attenuate the inflammation and promote the remyelination in EAE mice, which might be a promising cell source for the therapy of MS.
American Psychological Association (APA)
Shu, Jun& He, Xiaojuan& Li, Hong& Liu, Xue& Qiu, Xuemei& Zhou, Tongliang…[et al.]. 2018. The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192470
Modern Language Association (MLA)
Shu, Jun…[et al.]. The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192470
American Medical Association (AMA)
Shu, Jun& He, Xiaojuan& Li, Hong& Liu, Xue& Qiu, Xuemei& Zhou, Tongliang…[et al.]. The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192470