Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars
المؤلفون المشاركون
Zurac, Sabina
Popp, Cristiana
Nichita, Luciana
Cioplea, Mirela
Stinga, Patricia Irina
Bucur, Mihai
Dinca, Octavian
Vladan, Cristian
Mustatea, Petronel
Ionescu, Ecaterina
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-28
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Wound healing is a complex biologic process evolving in three phases: inflammation, proliferation, and tissue remodeling controlled by numerous growth factors and cytokines.
Oral mucosa wounds heal with significantly less important scars with less numerous macrophages and mast cells and more numerous myofibroblasts than cutaneous counterparts.
We analyzed 32 cutaneous and 32 oral mucosa scars for TGFbeta1, TGFbeta2, TGFbeta3, TNFalpha, PDGF BB and FGF1 expression in mesenchymal cells, endothelial cells, macrophages, and multinucleated giant cells.
We identified differences in the expression of profibrotic and antifibrotic factors in oral mucosa and skin scars; TGFbeta2 was positive in cutaneous multinucleated giant cells, TNFalpha was positive in cutaneous macrophages, and both were negative in oral mucosa while TGFbeta3 was positive in oral macrophages and mostly negative in cutaneous ones.
PDGF BB and FGF1 were positive in oral endothelial cells and oral macrophages and negative in macrophages with opposite positivity pattern in cutaneous scars.
Based on these findings, macrophage seems to be the key player in modulating pro- and antifibrotic processes in wound regeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bucur, Mihai& Dinca, Octavian& Vladan, Cristian& Popp, Cristiana& Nichita, Luciana& Cioplea, Mirela…[et al.]. 2018. Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1192501
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bucur, Mihai…[et al.]. Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars. Journal of Immunology Research No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1192501
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bucur, Mihai& Dinca, Octavian& Vladan, Cristian& Popp, Cristiana& Nichita, Luciana& Cioplea, Mirela…[et al.]. Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1192501
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192501
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر