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Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars
Joint Authors
Zurac, Sabina
Popp, Cristiana
Nichita, Luciana
Cioplea, Mirela
Stinga, Patricia Irina
Bucur, Mihai
Dinca, Octavian
Vladan, Cristian
Mustatea, Petronel
Ionescu, Ecaterina
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Wound healing is a complex biologic process evolving in three phases: inflammation, proliferation, and tissue remodeling controlled by numerous growth factors and cytokines.
Oral mucosa wounds heal with significantly less important scars with less numerous macrophages and mast cells and more numerous myofibroblasts than cutaneous counterparts.
We analyzed 32 cutaneous and 32 oral mucosa scars for TGFbeta1, TGFbeta2, TGFbeta3, TNFalpha, PDGF BB and FGF1 expression in mesenchymal cells, endothelial cells, macrophages, and multinucleated giant cells.
We identified differences in the expression of profibrotic and antifibrotic factors in oral mucosa and skin scars; TGFbeta2 was positive in cutaneous multinucleated giant cells, TNFalpha was positive in cutaneous macrophages, and both were negative in oral mucosa while TGFbeta3 was positive in oral macrophages and mostly negative in cutaneous ones.
PDGF BB and FGF1 were positive in oral endothelial cells and oral macrophages and negative in macrophages with opposite positivity pattern in cutaneous scars.
Based on these findings, macrophage seems to be the key player in modulating pro- and antifibrotic processes in wound regeneration.
American Psychological Association (APA)
Bucur, Mihai& Dinca, Octavian& Vladan, Cristian& Popp, Cristiana& Nichita, Luciana& Cioplea, Mirela…[et al.]. 2018. Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1192501
Modern Language Association (MLA)
Bucur, Mihai…[et al.]. Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars. Journal of Immunology Research No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1192501
American Medical Association (AMA)
Bucur, Mihai& Dinca, Octavian& Vladan, Cristian& Popp, Cristiana& Nichita, Luciana& Cioplea, Mirela…[et al.]. Variation in Expression of Inflammation-Related Signaling Molecules with Profibrotic and Antifibrotic Effects in Cutaneous and Oral Mucosa Scars. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1192501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192501