New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress
المؤلفون المشاركون
Căruntu, Constantin
Nicolae, Ilinca
Popa, Ioan Mircea
Tampa, Mircea
Mitran, Madalina
Mitran, Cristina
Sarbu, Isabela
Matei, Clara
Georgescu, Simona-Roxana
Tocut, Sandra Milena
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Human papillomavirus (HPV) is a small double-stranded DNA virus with tropism for epithelial cells.
To this date, over 150 genotypes are known and are classified into two major groups, low-risk and high-risk strains, depending on the ability of the virus to induce malignant transformation.
The host’s immunity plays a central role in the course of the infection; therefore, it may not be clinically manifest or may produce various benign or malignant lesions.
The pathogenic mechanisms are complex and incompletely elucidated.
Recent research suggests the role of chronic inflammation and oxidative stress (OS) in the pathogenesis of HPV infection and the associated carcinogenic processes.
Chronic inflammation induces OS, which in turn promotes the perpetuation of the inflammatory process resulting in the release of numerous molecules which cause cell damage.
Reactive oxygen species exert a harmful effect on proteins, lipids, and nucleic acids.
Viral oncogenes E5, E6, and E7 are involved in the development of chronic inflammation through various mechanisms.
In addition, HPV may interfere with redox homeostasis of host cells, inducing OS which may be involved in the persistence of the infection and play a certain role in viral integration and promotion of carcinogenesis.
Knowledge regarding the interplay between chronic inflammation and OS in the pathogenesis of HPV infection and HPV-induced carcinogenesis has important consequences on the development of new therapeutic strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Georgescu, Simona-Roxana& Mitran, Cristina& Mitran, Madalina& Căruntu, Constantin& Sarbu, Isabela& Matei, Clara…[et al.]. 2018. New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Georgescu, Simona-Roxana…[et al.]. New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Georgescu, Simona-Roxana& Mitran, Cristina& Mitran, Madalina& Căruntu, Constantin& Sarbu, Isabela& Matei, Clara…[et al.]. New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر