New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress
Joint Authors
Căruntu, Constantin
Nicolae, Ilinca
Popa, Ioan Mircea
Tampa, Mircea
Mitran, Madalina
Mitran, Cristina
Sarbu, Isabela
Matei, Clara
Georgescu, Simona-Roxana
Tocut, Sandra Milena
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Human papillomavirus (HPV) is a small double-stranded DNA virus with tropism for epithelial cells.
To this date, over 150 genotypes are known and are classified into two major groups, low-risk and high-risk strains, depending on the ability of the virus to induce malignant transformation.
The host’s immunity plays a central role in the course of the infection; therefore, it may not be clinically manifest or may produce various benign or malignant lesions.
The pathogenic mechanisms are complex and incompletely elucidated.
Recent research suggests the role of chronic inflammation and oxidative stress (OS) in the pathogenesis of HPV infection and the associated carcinogenic processes.
Chronic inflammation induces OS, which in turn promotes the perpetuation of the inflammatory process resulting in the release of numerous molecules which cause cell damage.
Reactive oxygen species exert a harmful effect on proteins, lipids, and nucleic acids.
Viral oncogenes E5, E6, and E7 are involved in the development of chronic inflammation through various mechanisms.
In addition, HPV may interfere with redox homeostasis of host cells, inducing OS which may be involved in the persistence of the infection and play a certain role in viral integration and promotion of carcinogenesis.
Knowledge regarding the interplay between chronic inflammation and OS in the pathogenesis of HPV infection and HPV-induced carcinogenesis has important consequences on the development of new therapeutic strategies.
American Psychological Association (APA)
Georgescu, Simona-Roxana& Mitran, Cristina& Mitran, Madalina& Căruntu, Constantin& Sarbu, Isabela& Matei, Clara…[et al.]. 2018. New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192574
Modern Language Association (MLA)
Georgescu, Simona-Roxana…[et al.]. New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192574
American Medical Association (AMA)
Georgescu, Simona-Roxana& Mitran, Cristina& Mitran, Madalina& Căruntu, Constantin& Sarbu, Isabela& Matei, Clara…[et al.]. New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192574