Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice
المؤلفون المشاركون
Shevchenko, Marina A.
Bogorodskiy, Andrey O.
Troyanova, Natalia I.
Servuli, Ekaterina A.
Bolkhovitina, Elena L.
Büldt, Georg
Fahlke, Christoph
Gordeliy, Valentin I.
Gensch, Thomas
Borshchevskiy, Valentin I.
Sapozhnikov, Alexander M.
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Susceptibility to fungal infection is commonly associated with impaired neutrophil responses.
To study the mechanisms underlying this association, we investigated neutrophil recruitment to the conducting airway wall after Aspergillus fumigatus conidium inhalation in mouse models of drug-induced immunosuppression and antibody-mediated neutrophil depletion (neutropenia) by performing three-dimensional confocal laser-scanning microscopy of whole-mount primary bronchus specimens.
Actin staining enabled visualization of the epithelial and smooth muscle layers that mark the airway wall.
Gr-1+ or Ly6G+ neutrophils located between the epithelium and smooth muscles were considered airway wall neutrophils.
The number of airway wall neutrophils for immunocompetent, immunosuppressed, and neutropenic mice before and 6 h after A.
fumigatus infection were analyzed and compared.
Our results show that the number of conducting airway wall neutrophils in immunocompetent mice significantly increased upon inflammation, while a dramatic reduction in this number was observed following immunosuppression and neutropenia.
Interestingly, a slight increase in the infiltration of neutrophils into the airway wall was detected as a result of infection, even in immunosuppressed and neutropenic mice.
Taken together, these data indicate that neutrophils are present in intact conducting airway walls and the number elevates upon A.
fumigatus infection.
Conducting airway wall neutrophils are affected by both neutropenia and immunosuppression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shevchenko, Marina A.& Bogorodskiy, Andrey O.& Troyanova, Natalia I.& Servuli, Ekaterina A.& Bolkhovitina, Elena L.& Büldt, Georg…[et al.]. 2018. Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192594
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shevchenko, Marina A.…[et al.]. Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1192594
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shevchenko, Marina A.& Bogorodskiy, Andrey O.& Troyanova, Natalia I.& Servuli, Ekaterina A.& Bolkhovitina, Elena L.& Büldt, Georg…[et al.]. Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192594
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192594
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر